Two optimal mutation rates in obligate pathogens subject to deleterious mutation

DOI10.1016/J.JTBI.2011.01.033zbMath1405.92267OpenAlexW2160611933WikidataQ95450755 ScholiaQ95450755MaRDI QIDQ2413828

Brendan O'Fallon

Publication date: 17 September 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2011.01.033

zbMATH Keywords

virulencequasispeciesmutation ratepathogen evolutionRNA virus

Mathematics Subject Classification ID

Epidemiology (92D30) Problems related to evolution (92D15) Genetics and epigenetics (92D10)

Cites Work

• Optimal viral production
• A competitive exclusion principle for pathogen virulence
• Virus evolution within patients increases pathogenicity
• Evaluating the importance of within- and between-host selection pressures on the evolution of chronic pathogens
• Some basic properties of immune selection
• Optimizing within-host viral fitness: infected cell lifespan and virion production rate
• Modeling within-host evolution of HIV: mutation, competition and strain replacement
• Trade-offs and the evolution of virulence of microparasites: do details matter?
• Evolution of virulence: interdependence, constraints, and selection using nested models
• Epidemiology and genetics in the coevolution of parasites and hosts

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