A stochastic version of the Eigen model

DOI10.1007/S11538-010-9525-4MaRDI QIDQ2430573zbMATH OpenOpenAlexWikidataFDO

Authors Fabio Musso

Publication date 8 April 2011

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0901.3666

zbMATH Keywords

error thresholdmutation-selection dynamicsstochastic model

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Problems related to evolution (92D15)

Abstract: We exhibit a stochastic discrete time model that has exactly the Eigen model as its deterministic continuous limit. Such model can be divided into two phases: reproduction followed by neutral selection. This result suggests that Eigen model describes the competition among individuals differing for reproductive capability but equivalent as survivors. We explicitly write down the Markov matrix of the stochastic model in the two species case and compute numerically the master sequence concentration for various values of the total population. Finally we compare our results with those obtained with Eigen model and with Nowak and Schuster birth and death model.

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• Expansion of the master equation for a biomolecular selection model
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Cites work

• A stochastic theory of macromolecular evolution
• Finite-size scaling of the error threshold transition in finite populations
• Global stability of genetic systems governed by mutation and selection
• On Eigen's theory of the self-organization of matter and the evolution of biological macromolecules
• On the theory of selection of coupled macromolecular systems
• Polynucleotide evolution and branching processes
• Stochastic analysis of a nonlinear model for selection of biological macromolecules
• Stochastic model of evolving populations

Cited in

(9)

• Expansion of the master equation for a biomolecular selection model
• Eigen-stratified models
• Critical population and error threshold on the sharp peak landscape for the Wright-Fisher model
• Convergence of a Moran model to Eigen's quasispecies model
• The distribution of the quasispecies for a Moran model on the sharp peak landscape
• Mathematical formalization of the process of crossing individuals of different populations within the framework of the quasispecies model
• On the relation between the Eigen model and the asexual Wright-Fisher model
• The distribution of the quasispecies for the Wright-Fisher model on the sharp peak landscape
• Critical population and error threshold on the sharp peak landscape for a Moran model

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