Modeling effect of a \(\gamma \)-secretase inhibitor on amyloid-\(\beta \) dynamics reveals significant role of an amyloid clearance mechanism

DOI10.1007/S11538-010-9540-5zbMath1209.92027OpenAlexW2037361493WikidataQ44115983 ScholiaQ44115983MaRDI QIDQ2430580

Jeffrey Saltzman, Robert B. Nachbar, Leah Edelstein-Keshet, Raibatak Das, Matthew C. Wiener

Publication date: 8 April 2011

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-010-9540-5

zbMATH Keywords

\(\gamma\)-secretase inhibitoramyloid-\(\beta\) clearance

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Cites Work

• A mathematical model of the impact of novel treatments on the A\(\beta\) burden in the Alzheimer's brain, CSF and plasma
• Unnamed Item

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