Estimation of statistical binding properties of ligand population during in vitro selection based on population dynamics theory

DOI10.1016/J.MBS.2013.10.012MaRDI QIDQ2441606zbMATH OpenOpenAlexWikidataFDO

Authors Takuyo Aita, Koichi Nishigaki, Yuzuru Husimi

Publication date 25 March 2014

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2013.10.012

zbMATH Keywords

aptamerbinding constantsdirected evolutionevolutionmonitoring methodselex

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Computational methods for problems pertaining to biology (92-08) Problems related to evolution (92D15)

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Cites work

• Hierarchical distribution of ascending slopes, nearly neutral networks, highlands, and local optima at the \(d\)th order in an NK fitness landscape
• The bootstrap and Edgeworth expansion
• Theoretical consideration of selective enrichment in in vitro selection: optimal concentration of target molecules
• Toward the fast blind docking of a peptide to a target protein by using a four-body statistical pseudo-potential

Cited in

(3)

• Statistical methods for estimating complexity from competition experiments between two populations
• Theoretical consideration of selective enrichment in in vitro selection: optimal concentration of target molecules
• Mathematical consideration of massive estimation of dissociation rate constant for genotype-phenotype linking molecules bound to targets through washing/selection and next-generation sequencing

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