Maximin and maximin-efficient event-related fMRI designs under a nonlinear model
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Abstract: Previous studies on event-related functional magnetic resonance imaging experimental designs are primarily based on linear models, in which a known shape of the hemodynamic response function (HRF) is assumed. However, the HRF shape is usually uncertain at the design stage. To address this issue, we consider a nonlinear model to accommodate a wide spectrum of feasible HRF shapes, and propose efficient approaches for obtaining maximin and maximin-efficient designs. Our approaches involve a reduction in the parameter space and a search algorithm that helps to efficiently search over a restricted class of designs for good designs. The obtained designs are compared with traditional designs widely used in practice. We also demonstrate the usefulness of our approaches via a motivating example.
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Cited in
(7)- Maximin and maximin-efficient event-related fMRI designs under a nonlinear model
- A new type of experimental designs for event-related fMRI via Hadamard matrices
- Optimal and efficient designs for functional brain imaging experiments
- Some limit results for efficiency in stochastic fMRI designs
- A fast algorithm for constructing efficient event-related functional magnetic resonance imaging designs
- An investigation of a quadratic design criterion for estimation of the hemodynamic response function
- Optimal experimental designs for sparse functional data: a review
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