A path integral formulation of the Wright-Fisher process with genic selection

DOI10.1016/J.TPB.2013.11.002MaRDI QIDQ2444778zbMATH OpenOpenAlexWikidataFDO

Authors Joshua G. Schraiber

Publication date 11 April 2014

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1307.7756

zbMATH Keywords

diffusion theorypath integralperturbation theoryWright-Fisher

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Genetics and epigenetics (92D10) Population dynamics (general) (92D25)

Abstract: The Wright-Fisher process with selection is an important tool in population genetics theory. Traditional analysis of this process relies on the diffusion approximation. The diffusion approximation is usually studied in a partial differential equations framework. In this paper, I introduce a path integral formalism to study the Wright-Fisher process with selection and use that formalism to obtain a simple perturbation series to approximate the transition density. The perturbation series can be understood in terms of Feynman diagrams, which have a simple probabilistic interpretation in terms of selective events. The perturbation series proves to be an accurate approximation of the transition density for weak selection and is shown to be arbitrarily accurate for any selection coefficient.

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Cited in

(4)

• Elliptic and other functions in the large deviations behavior of the Wright-Fisher process
• Path integral formulation and Feynman rules for phylogenetic branching models
• The evolution of moment generating functions for the Wright-Fisher model of population genetics
• A stochastic field theory for the evolution of quantitative traits in finite populations

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