Locally D-optimal designs based on a class of composed models resulted from blending Emax and one-compartment models

DOI10.1214/009053607000000776MaRDI QIDQ2477067zbMATH OpenOpenAlexFDO

Authors Yanyan Li

Publication date 12 March 2008

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0803.2108, https://projecteuclid.org/euclid.aos/1201877308

zbMATH Keywords

nonlinear modelpharmacodynamic Emax modelpharmacokinetic compartmental model

Mathematics Subject Classification ID

Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: A class of nonlinear models combining a pharmacokinetic compartmental model and a pharmacodynamic Emax model is introduced. The locally D-optimal (LD) design for a four-parameter composed model is found to be a saturated four-point uniform LD design with the two boundary points of the design space in the LD design support. For a five-parameter composed model, a sufficient condition for the LD design to require the minimum number of sampling time points is derived. Robust LD designs are also investigated for both models. It is found that an LD design with $k$ parameters is equivalent to an LD design with $k-1$ parameters if the linear parameter in the two composed models is a nuisance parameter. Assorted examples of LD designs are presented.

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Cites work

• An extension of the General Equivalence Theorem to nonlinear models
• Bayesian D-optimal designs for exponential regression models
• Bayesian Experimental Design for Nonlinear Mixed‐Effects Models with Application to HIV Dynamics
• D- and c-optimal designs for exponential regression models used in viral dynamics and other applications
• Generalized Nonlinear Models for Pharmacokinetic Data
• scientific article; zbMATH DE number 3734989 (Why is no real title available?)
• scientific article; zbMATH DE number 3763103 (Why is no real title available?)
• scientific article; zbMATH DE number 3246461 (Why is no real title available?)
• Modeling and Identifying Optimum Designs for Fitting Dose-Response Curves Based on Raw Optical Density Data
• Optimal and efficient designs for 2-parameter nonlinear models
• Optimal design in random-effects regression models
• Optimum designs for estimating \(ED_p\) based on raw optical density data
• Optimum Experimental Designs for Properties of a Compartmental Model
• The Bayesian Analysis of Population Pharmacokinetic Models
• The Equivalence of Two Extremum Problems
• Übersichtsarbeiten

Cited in

(10)

• Complete classes of designs for nonlinear regression models and principal representations of moment spaces
• Optimal designs for nonlinear regression models with respect to non-informative priors
• Optimal designs for some selected nonlinear models
• Optimal designs for quantile regression models
• A note on the de la Garza phenomenon for locally optimal designs
• Bayesian Φ _q -optimal designs for multi-factor additive non linear models with heteroscedastic errors
• Analysis of clinical trials with biologics using dose-time-response models
• Optimal design of clinical trials with biologics using dose-time-response models
• On the efficiency of two-stage response-adaptive designs
• On the de la Garza phenomenon

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