Narrow escape. III: Non-smooth domains and Riemann surfaces

DOI10.1007/S10955-005-8028-4MaRDI QIDQ2492783zbMATH OpenOpenAlexWikidataFDO

Authors A. Singer, D. Holcman, Zeev Schuss

Publication date 14 June 2006

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math-ph/0412051

Mathematics Subject Classification ID

Boundary value problems for second-order elliptic equations (35J25) Brownian motion (60J65) Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Neural biology (92C20)

Abstract: We consider Brownian motion in a bounded domain $Omega$ on a two-dimensional Riemannian manifold $(Sigma,g)$. We assume that the boundary $pOmega$ is smooth and reflects the trajectories, except for a small absorbing arc $pOmeg{a}_{a}subsetpOmega$. As $pOmeg{a}_a$ is shrunk to zero the expected time to absorption in $pOmeg{a}_a$ becomes infinite. The narrow escape problem consists in constructing an asymptotic expansion of the expected lifetime, denoted $Eau$, as $epsilon=|partialOmeg{a}_a{|}_g/|partialOmega{|}_{g}o0$. We derive a leading order asymptotic approximation $Eau=dsfrac|Omega{|}_{g}Dpi[logdsfrac1epsilon+O(1)]$. The order 1 term can be evaluated for simply connected domains on a sphere by projecting stereographically on the complex plane and mapping conformally on a circular disk. It can also be evaluated for domains that can be mapped conformally onto an annulus. This term is needed in real life applications, such as trafficking of receptors on neuronal spines, because $logdsfrac1epsilon$ is not necessarily large, even when $epsilon$ is small. If the absorbing window is located at a corner of angle $alpha$, then $Eau=dsfrac|Omega{|}_{g}Dalpha[logdsfrac1epsilon+O(1)],$ if near a cusp, then $Eau$ grows algebraically, rather than logarithmically. Thus, in the domain bounded between two tangent circles, the expected lifetime is $Eau=dsfrac|Omega|(d^{-1}-1)D(frac1epsilon+O(1))$.

Recommendations

• Narrow escape. II: The circular disk
• Narrow escape. I
• An asymptotic analysis of the mean first passage time for narrow escape problems. I: Two-dimensional domains
• The narrow escape problem
• Asymptotic analysis for the narrow escape problem

Cites work

• Escape through a small opening: receptor trafficking in a synaptic membrane
• scientific article; zbMATH DE number 3686457 (Why is no real title available?)
• scientific article; zbMATH DE number 43978 (Why is no real title available?)
• scientific article; zbMATH DE number 50750 (Why is no real title available?)
• scientific article; zbMATH DE number 1081462 (Why is no real title available?)
• scientific article; zbMATH DE number 3201835 (Why is no real title available?)
• scientific article; zbMATH DE number 3226385 (Why is no real title available?)
• scientific article; zbMATH DE number 3186692 (Why is no real title available?)
• scientific article; zbMATH DE number 3196936 (Why is no real title available?)
• Narrow escape. II: The circular disk

Cited in

(32)

• Analysis of the Poisson-Nernst-Planck equation in a ball for modeling the voltage-current relation in neurobiological microdomains
• The narrow escape problem -- a short review of recent results
• Diffusion laws in dendritic spines
• Post-transcriptional regulation in the nucleus and cytoplasm: study of mean time to threshold (MTT) and narrow escape problem
• Exit time distribution in spherically symmetric two-dimensional domains
• Modeling DNA and virus trafficking in the cell cytoplasm
• Extended narrow escape with many windows for analyzing viral entry into the cell nucleus
• Asymptotic formulas for extreme statistics of escape times in 1, 2 and 3-dimensions
• Narrow escape. I
• Narrow escape. II: The circular disk
• 100 years after Smoluchowski: stochastic processes in cell biology
• Survival probability of random walks leaping over traps
• Statistics of diffusive encounters with a small target: three complementary approaches
• Statistics of the maximum and the convex hull of a Brownian motion in confined geometries
• Transport properties of diffusive particles conditioned to survive in trapping environments
• First-passage times of multiple diffusing particles with reversible target-binding kinetics
• From first-passage times of random walks in confinement to geometry-controlled kinetics
• Spot patterns of the Schnakenberg reaction-diffusion system on a curved torus
• Analytical solutions for an escape problem in a disc with an arbitrary distribution of exit holes along its boundary
• The narrow escape problem in a circular domain with radial piecewise constant diffusivity
• Effects of target anisotropy on harmonic measure and mean first-passage time
• Statistical and transport properties of a one-dimensional random walk with periodically distributed trapping intervals
• The narrow capture problem on general Riemannian surfaces.
• Narrow escape problem in the presence of the force field
• Some questions related to modeling in cellular biology
• The mean first rotation time of a planar polymer
• Optimizing the principal eigenvalue of the Laplacian in a sphere with interior traps
• Diffusion through a cluster of small windows and flux regulation in microdomains
• Layer potential techniques for the narrow escape problem
• Cellular diffusion processes in singularly perturbed domains
• Steklov-Neumann spectral problem: asymptotic analysis and applications to diffusion-controlled reactions
• Mean exit time for surface-mediated diffusion: spectral analysis and asymptotic behavior

This page was built for publication: Narrow escape. III: Non-smooth domains and Riemann surfaces

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2492783)