Intracellular regulation of cell signaling cascades: how location makes a difference

DOI10.1007/S00285-013-0701-7MaRDI QIDQ2510397zbMATH OpenOpenAlexWikidataFDO

Authors Yongyun Hwang, Praveen Kumar, Abdul I. Barakat

Publication date 1 August 2014

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-013-0701-7

zbMATH Keywords

adjoint variablescell signalingendocytosisMAP kinasesensitivity analysis

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• Spatially-localized scaffold proteins may facilitate to transmit long-range signals
• Model of cell signal transduction in a three-dimensional domain
• Crosstalk facilitates spatial signal propagation through MAPK cascades
• On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling
• A kinetic model of ERK cyclic pathway on substrate control

Cites work

• Perspectives in Flow Control and Optimization
• Signaling cascades as cellular devices for spatial computations

Cited in

(1)

• Spatially-localized scaffold proteins may facilitate to transmit long-range signals

This page was built for publication: Intracellular regulation of cell signaling cascades: how location makes a difference

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2510397)