Modelling in vivo action potential propagation along a giant axon

DOI10.1007/S00285-013-0751-XMaRDI QIDQ2512931zbMATH OpenOpenAlexWikidataFDO

Authors Stuart George, J. M. Foster, Giles Richardson

Publication date 2 February 2015

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://researchportal.port.ac.uk/portal/en/publications/modelling-in-vivo-action-potential-propagation-along-a-giant-axon(fe4db77d-bc66-4816-9928-f64ed722dfd3).html

zbMATH Keywords

action potentialcable equationelectrochemistryHodgkin-Huxley modelpartial differential equationsingular integral equationssquid giant axon

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biophysics (92C05) Neural biology (92C20)

Review text

The authors study a partial differential equation model for current flow in a three-dimensional cylindrical axon. They consider two cases: the conductivity of the surrounding tissue is (i) significantly lower than that of the intracellular space, and (ii) equal to that of the intracellular space. Case (i) represents the in vivo setting, while case (ii) represents the in vitro setting. The authors compare the results of simulating the PDE with those obtained by simulating the one-dimensional cable equation and find good agreement in case (ii) but marked differences in both wave profile and speed of action potential propagation in case (i). They investigate the scaling of wave speed with axon radius (it scales as the square root of the radius) but find that the speed is significantly higher in vitro than in vivo. Regarding maximising the speed of action potential propagation, they suggest that despite their results, metabolic cost is still a limiting factor in determining the size of an axon.

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Cites work

• A multiscale approach to modelling electrochemical processes occurring across the cell membrane with application to transmission of action potentials
• Derivation of the bidomain equations for a beating heart with a general microstructure
• Spiking Neuron Models

Cited in

(12)

• Modeling the interactions between stimulation and physiologically induced APs in a mammalian nerve fiber: dependence on frequency and fiber diameter
• Modeling mitochondrial dynamics during in vivo axonal elongation
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• A note on the discrepancy between the predicted and observed speed of the propagated action potential in the squid giant axon
• Electric potential generation of electrocytes: modelling, analysis, and computation
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• On the complexity of signal propagation in nerve fibres
• A study on the modeling and simulation for the motor unit action potential
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