A maximum principle for the mutation-selection equilibrium of nucleotide sequences

DOI10.1016/J.BULM.2003.08.013zbMATH Open1334.92270arXivphysics/0303053OpenAlexW3104145738WikidataQ42621641 ScholiaQ42621641MaRDI QIDQ253530FDOQ253530

Authors: Tini Garske, Uwe Grimm 

Publication date: 8 March 2016

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We study the equilibrium behaviour of a deterministic four-state mutation-selection model as a model for the evolution of a population of nucleotide sequences in sequence space. The mutation model is the Kimura 3ST mutation scheme, and the selection scheme is assumed to be invariant under permutation of sites. Considering the evolution process both forward and backward in time, we use the ancestral distribution as the stationary state of the backward process to derive an expression for the mutational loss (as the difference between ancestral and population mean fitness), and we prove a maximum principle that determines the population mean fitness in mutation-selection balance.

Full work available at URL: https://arxiv.org/abs/physics/0303053

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zbMATH Keywords

Kimura 3ST mutation schememutation-selection balancemutation-selection equilibriumnucleotide sequences

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

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• Mutation-selection balance: ancestry, load, and maximum principle
• Maximum principle and mutation thresholds for four-letter sequence evolution
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