Mutation-selection balance: ancestry, load, and maximum principle

DOI10.1006/TPBI.2002.1582zbMATH Open1064.92032arXivcond-mat/0202432OpenAlexW2165214669WikidataQ74266429 ScholiaQ74266429MaRDI QIDQ2483953FDOQ2483953

Authors: Joachim Hermisson, O. Redner, Holger Wagner, Ellen Baake 

Publication date: 1 August 2005

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: We show how concepts from statistical physics, such as order parameter, thermodynamic limit, and quantum phase transition, translate into biological concepts in mutation-selection models for sequence evolution and can be used there. The article takes a biological point of view within a population genetics framework, but contains an appendix for physicists, which makes this correspondence clear. We analyze the equilibrium behavior of deterministic haploid mutation-selection models. Both the forward and the time-reversed evolution processes are considered. The stationary state of the latter is called the ancestral distribution, which turns out as a key for the study of mutation-selection balance. We find that it determines the sensitivity of the equilibrium mean fitness to changes in the fitness values and discuss implications for the evolution of mutational robustness. We further show that the difference between the ancestral and the population mean fitness, termed mutational loss, provides a measure for the sensitivity of the equilibrium mean fitness to changes in the mutation rate. For a class of models in which the number of mutations in an individual is taken as the trait value, and fitness is a function of the trait, we use the ancestor formulation to derive a simple maximum principle, from which the mean and variance of fitness and the trait may be derived; the results are exact for a number of limiting cases, and otherwise yield approximations which are accurate for a wide range of parameters. These results are applied to (error) threshold phenomena caused by the interplay of selection and mutation. They lead to a clarification of concepts, as well as criteria for the existence of thresholds.

Full work available at URL: https://arxiv.org/abs/cond-mat/0202432

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zbMATH Keywords

epistasisbranching processerror thresholdmutation-selection modelbackward processesmutational robustnessclonal reproductionmutation loadstatistical physics.

Mathematics Subject Classification ID

Problems related to evolution (92D15) Special processes (60K99) Applications of statistical mechanics to specific types of physical systems (82D99)

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Cited In (45)

• A maximum principle for the mutation-selection equilibrium of nucleotide sequences
• Error thresholds in a mutation-selection model with Hopfield-type fitness
• Generalized quasispecies model on finite metric spaces: isometry groups and spectral properties of evolutionary matrices
• Generation of variation and a modified mean fitness principle: necessity is the mother of genetic invention
• Spin coherent state representation of the Crow-Kimura and Eigen models of quasispecies theory
• Recombination and the evolution of mutational robustness
• Error thresholds for self- and cross-specific enzymatic replication
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• Non-equivalent loci and mutation-selection balance
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