Finite genome length corrections for the mean fitness and gene probabilities in evolution models

DOI10.1007/S10955-011-0254-3zbMATH Open1226.82032arXiv1212.1262OpenAlexW3101486046WikidataQ58429522 ScholiaQ58429522MaRDI QIDQ637532FDOQ637532

Zara Kirakosyan, D. B. Saakyan, Chin-Kun Hu

Publication date: 6 September 2011

Published in: Journal of Statistical Physics (Search for Journal in Brave)

Abstract: Using the Hamilton-Jacobi equation approach to study genomes of length $L$, we obtain 1/L corrections for the steady state population distributions and mean fitness functions for horizontal gene transfer model, as well as for the diploid evolution model with general fitness landscapes. Our numerical solutions confirm the obtained analytic equations. Our method could be applied to the general case of nonlinear Markov models.

Full work available at URL: https://arxiv.org/abs/1212.1262

zbMATH Keywords

evolution modelsdiploidsfinite size correctionshorizontal gene transfer (HGT)UJE

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Protein sequences, DNA sequences (92D20) Hamilton-Jacobi equations (35F21) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Classical dynamic and nonequilibrium statistical mechanics (general) (82C05)

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Cited In (3)

• Title not available (Why is that?)
• Quantifying the impact of changes in effective population size and expression level on the rate of coding sequence evolution
• Exact solutions for the selection-mutation equilibrium in the Crow-Kimura evolutionary model

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