Finite genome length corrections for the mean fitness and gene probabilities in evolution models

DOI10.1007/S10955-011-0254-3zbMATH Open1226.82032OpenAlexW3101486046WikidataQ58429522 ScholiaQ58429522MaRDI QIDQ637532FDOQ637532

Authors Zara Kirakosyan, D. B. Saakyan, Chin-Kun Hu 

Publication date 6 September 2011

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1212.1262

zbMATH Keywords

evolution modelsdiploidsfinite size correctionshorizontal gene transfer (HGT)UJE

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Protein sequences, DNA sequences (92D20) Hamilton-Jacobi equations (35F21) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Classical dynamic and nonequilibrium statistical mechanics (general) (82C05)

Abstract: Using the Hamilton-Jacobi equation approach to study genomes of length $L$, we obtain 1/L corrections for the steady state population distributions and mean fitness functions for horizontal gene transfer model, as well as for the diploid evolution model with general fitness landscapes. Our numerical solutions confirm the obtained analytic equations. Our method could be applied to the general case of nonlinear Markov models.

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Cites work

• scientific article; zbMATH DE number 3390587 (Why is no real title available?)
• A new method for the solution of models of biological evolution: Derivation of exact steady-state distributions
• Error threshold in simple landscapes
• Mathematical population genetics. I: Theoretical introduction.
• Mutation-selection balance: ancestry, load, and maximum principle
• On Eigen's theory of the self-organization of matter and the evolution of biological macromolecules
• Schwinger boson formulation and solution of the crow-kimura and eigen models of quasispecies theory

Cited in

(3)

• scientific article; zbMATH DE number 1439488 (Why is no real title available?)
• Quantifying the impact of changes in effective population size and expression level on the rate of coding sequence evolution
• Exact solutions for the selection-mutation equilibrium in the Crow-Kimura evolutionary model

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