Virus replication as a phenotypic version of polynucleotide evolution
From MaRDI portal
Publication:376449
DOI10.1007/S11538-013-9822-9zbMATH Open1310.92036arXiv1204.6353OpenAlexW2023282897WikidataQ43969579 ScholiaQ43969579MaRDI QIDQ376449FDOQ376449
Authors: Fernando Antoneli, Francisco Bosco, Diogo Castro, Luiz Mario Ramos Janini 
Publication date: 5 November 2013
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in their study of polynucleotide evolution. By taking into account beneficial effects we obtain a non-trivial multivariate generalization of their single-type branching process model. Perturbative techniques allows us to obtain analytical asymptotic expressions for the main global parameters of the model which lead to the following rigorous results: (i) a new criterion for "no sure extinction", (ii) a generalization and proof, for this particular class of models, of the lethal mutagenesis criterion proposed by Bull, Sanju'an and Wilke ("Theory of lethal mutagenesis for viruses", J. Virology 18 (2007) 2930-2939), (iii) a new proposal for the notion of relaxation time with a quantitative prescription for its evaluation, (iv) the quantitative description of the evolution of the expected values in in four distinct "stages": extinction threshold, lethal mutagenesis, stationary "equilibrium" and transient. Finally, based on these quantitative results we are able to draw some qualitative conclusions.
Full work available at URL: https://arxiv.org/abs/1204.6353
Recommendations
- A branching process for virus survival
- Polynucleotide evolution and branching processes
- Coinfection and superinfection in RNA virus populations: A selection--mutation model
- Viral replication modes in single-peak fitness landscapes: a dynamical systems analysis
- Stochastic modeling and simulation of viral evolution
Cites Work
- Title not available (Why is that?)
- Title not available (Why is that?)
- Title not available (Why is that?)
- Title not available (Why is that?)
- On Eigen's theory of the self-organization of matter and the evolution of biological macromolecules
- Mutation-selection balance: ancestry, load, and maximum principle
- Title not available (Why is that?)
- Title not available (Why is that?)
- Polynucleotide evolution and branching processes
- Toeplitz and circulant matrices: a review.
- Title not available (Why is that?)
- Title not available (Why is that?)
- Branching processes in biology
- Patterns of synchrony in lattice dynamical systems
- Markovian paths to extinction
- A trade-off between neutrality and adaptability limits the optimization of viral quasispecies
- Virus replication as a phenotypic version of polynucleotide evolution
- Evolutionary entropy predicts the outcome of selection: competition for resources that vary in abundance and diversity
- Huge progeny production during the transient of a quasi-species model of viral infection, reproduction and mutation
Cited In (9)
- Coinfection and superinfection in RNA virus populations: A selection--mutation model
- Polynucleotide evolution and branching processes
- Lethal mutagenesis in a structured environment
- A branching process for virus survival
- Order reduction for an RNA virus evolution model
- Stochastic modeling and simulation of viral evolution
- Distribution of the quasispecies for a Galton-Watson process on the sharp peak landscape
- Virus replication as a phenotypic version of polynucleotide evolution
- Viral replication modes in single-peak fitness landscapes: a dynamical systems analysis
This page was built for publication: Virus replication as a phenotypic version of polynucleotide evolution
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q376449)
