Virus replication as a phenotypic version of polynucleotide evolution
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Publication:376449
Abstract: In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in their study of polynucleotide evolution. By taking into account beneficial effects we obtain a non-trivial multivariate generalization of their single-type branching process model. Perturbative techniques allows us to obtain analytical asymptotic expressions for the main global parameters of the model which lead to the following rigorous results: (i) a new criterion for "no sure extinction", (ii) a generalization and proof, for this particular class of models, of the lethal mutagenesis criterion proposed by Bull, Sanju'an and Wilke ("Theory of lethal mutagenesis for viruses", J. Virology 18 (2007) 2930-2939), (iii) a new proposal for the notion of relaxation time with a quantitative prescription for its evaluation, (iv) the quantitative description of the evolution of the expected values in in four distinct "stages": extinction threshold, lethal mutagenesis, stationary "equilibrium" and transient. Finally, based on these quantitative results we are able to draw some qualitative conclusions.
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- Virus replication as a phenotypic version of polynucleotide evolution
Cited in
(9)- A branching process for virus survival
- Stochastic modeling and simulation of viral evolution
- Coinfection and superinfection in RNA virus populations: A selection--mutation model
- Virus replication as a phenotypic version of polynucleotide evolution
- Polynucleotide evolution and branching processes
- Viral replication modes in single-peak fitness landscapes: a dynamical systems analysis
- Lethal mutagenesis in a structured environment
- Distribution of the quasispecies for a Galton-Watson process on the sharp peak landscape
- Order reduction for an RNA virus evolution model
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