Linear algebra of the permutation invariant Crow-Kimura model of prebiotic evolution

DOI10.1016/J.MBS.2014.08.006zbMATH Open1330.92084arXiv1306.0111OpenAlexW2963289259WikidataQ51051432 ScholiaQ51051432MaRDI QIDQ464501FDOQ464501

Artem S. Novozhilov, Yuri S. Semenov, Alexander S. Bratus

Publication date: 27 October 2014

Published in: Mathematical Biosciences (Search for Journal in Brave)

Abstract: A particular case of the famous quasispecies model - the Crow-Kimura model with a permutation invariant fitness landscape - is investigated. Using the fact that the mutation matrix in the case of a permutation invariant fitness landscape has a special tridiagonal form, a change of the basis is suggested such that in the new coordinates a number of analytical results can be obtained. In particular, using the eigenvectors of the mutation matrix as the new basis, we show that the quasispecies distribution approaches a binomial one and give simple estimates for the speed of convergence. Another consequence of the suggested approach is a parametric solution to the system of equations determining the quasispecies. Using this parametric solution we show that our approach leads to exact asymptotic results in some cases, which are not covered by the existing methods. In particular, we are able to present not only the limit behavior of the leading eigenvalue (mean population fitness), but also the exact formulas for the limit quasispecies eigenvector for special cases. For instance, this eigenvector has a geometric distribution in the case of the classical single peaked fitness landscape. On the biological side, we propose a mathematical definition, based on the closeness of the quasispecies to the binomial distribution, which can be used as an operational definition of the notorious error threshold. Using this definition, we suggest two approximate formulas to estimate the critical mutation rate after which the quasispecies delocalization occurs.

Full work available at URL: https://arxiv.org/abs/1306.0111

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zbMATH Keywords

error thresholdleading eigenvalueCrow-Kimura modelquasispecies modelsingle peaked fitness landscape

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Problems related to evolution (92D15) Special matrices (15B99)

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Cited In (10)

• On diffusive stability of Eigen's quasispecies model
• Open quasispecies models: stability, optimization, and distributed extension
• Generalized quasispecies model on finite metric spaces: isometry groups and spectral properties of evolutionary matrices
• On Eigen's quasispecies model, two-valued fitness landscapes, and isometry groups acting on finite metric spaces
• Quasispecies on class-dependent fitness landscapes
• Exact solutions for the selection-mutation equilibrium in the Crow-Kimura evolutionary model
• Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states
• A linear algebra model for quasispecies
• On the behavior of the leading eigenvalue of Eigen's evolutionary matrices
• The exact solution of the mutator model with directed mutations, linear fitness function, and finite genome length

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