A probabilistic view on the deterministic mutation-selection equation: dynamics, equilibria, and ancestry via individual lines of descent

DOI10.1007/S00285-018-1228-8zbMATH Open1408.92015arXiv1710.04573OpenAlexW2761174995WikidataQ52381341 ScholiaQ52381341MaRDI QIDQ667706FDOQ667706

Authors: Ellen Baake, Fernando Cordero, Sebastian Hummel 

Publication date: 1 March 2019

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We reconsider the deterministic haploid mutation-selection equation with two types. This is an ordinary differential equation that describes the type distribution (forward in time) in a population of infinite size. This paper establishes ancestral (random) structures inherent in this deterministic model. In a first step, we obtain a representation of the deterministic equation's solution (and, in particular, of its equilibrium) in terms of an ancestral process called the killed ancestral selection graph. This representation allows one to understand the bifurcations related to the error threshold phenomenon from a genealogical point of view. Next, we characterise the ancestral type distribution by means of the pruned lookdown ancestral selection graph and study its properties at equilibrium. We also provide an alternative characterisation in terms of a piecewise-deterministic Markov process. Throughout, emphasis is on the underlying dualities as well as on explicit results.

Full work available at URL: https://arxiv.org/abs/1710.04573

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zbMATH Keywords

error thresholdkilled ancestral selection graphmutation-selection equationpruned lookdown ancestral selection graph

Mathematics Subject Classification ID

Applications of graph theory (05C90) Problems related to evolution (92D15)

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Cited In (11)

• Quasi-equilibria and click times for a variant of Muller's ratchet
• The evolving Moran genealogy
• Labeled partitions in action: recombination, selection, mutation and more
• Lines of descent in a Moran model with frequency-dependent selection and mutation
• Solving the selection-recombination equation: ancestral lines and dual processes
• On the stationary distribution of the block counting process for population models with mutation and selection
• Mutation-selection balance: ancestry, load, and maximum principle
• Lines of descent under selection
• Population dynamics and statistical physics in synergy. Abstracts from the workshop held March 6--12, 2022
• Lines of descent in the deterministic mutation-selection model with pairwise interaction
• General selection models: Bernstein duality and minimal ancestral structures

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