Solving the selection-recombination equation: ancestral lines and dual processes
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Publication:2035567
Abstract: The deterministic selection-recombination equation describes the evolution of the genetic type composition of a population under selection and recombination in a law of large numbers regime. So far, an explicit solution has seemed out of reach; only in the special case of three sites with selection acting on one of them has an approximate solution been found, but without an obvious path to generalisation. We use both an analytical and a probabilistic, genealogical approach for the case of an emph{arbitrary} number of neutral sites linked to one selected site. This leads to a recursive integral representation of the solution. Starting from a variant of the ancestral selection-recombination graph, we develop an efficient genealogical structure, which may, equivalently, be represented as a weighted partitioning process, a family of Yule processes with initiation and resetting, and a family of initiation processes. We prove them to be dual to the solution of the differential equation forward in time and thus obtain a stochastic representation of the deterministic solution, along with the Markov semigroup in closed form.
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Cited in
(8)- Solving the migration-recombination equation from a genealogical point of view
- Labeled partitions in action: recombination, selection, mutation and more
- Selection, recombination, and the ancestral initiation graph
- Mutation and recombination with tight linkage
- Asymptotic sampling distributions made easy: loose linkage in the ancestral recombination graph
- Evolution with recombination as Gibbs sampling
- The recombination equation for interval partitions
- A probabilistic view on the deterministic mutation-selection equation: dynamics, equilibria, and ancestry via individual lines of descent
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