Solving the selection-recombination equation: ancestral lines and dual processes

DOI10.25537/DM.2021V26.743-793zbMATH Open1478.92126arXiv2003.06831MaRDI QIDQ2035567FDOQ2035567

Authors: Frederic Alberti, Ellen Baake 

Publication date: 25 June 2021

Published in: Documenta Mathematica (Search for Journal in Brave)

Abstract: The deterministic selection-recombination equation describes the evolution of the genetic type composition of a population under selection and recombination in a law of large numbers regime. So far, an explicit solution has seemed out of reach; only in the special case of three sites with selection acting on one of them has an approximate solution been found, but without an obvious path to generalisation. We use both an analytical and a probabilistic, genealogical approach for the case of an emph{arbitrary} number of neutral sites linked to one selected site. This leads to a recursive integral representation of the solution. Starting from a variant of the ancestral selection-recombination graph, we develop an efficient genealogical structure, which may, equivalently, be represented as a weighted partitioning process, a family of Yule processes with initiation and resetting, and a family of initiation processes. We prove them to be dual to the solution of the differential equation forward in time and thus obtain a stochastic representation of the deterministic solution, along with the Markov semigroup in closed form.

Full work available at URL: https://arxiv.org/abs/2003.06831

File on IPFS (Hint: this is only the Hash - if you get a timeout, this file is not available on our server.)

Recommendations

• Selection, recombination, and the ancestral initiation graph
• Solving the migration-recombination equation from a genealogical point of view
• The general recombination equation in continuous time and its solution
• A probabilistic view on the deterministic mutation-selection equation: dynamics, equilibria, and ancestry via individual lines of descent
• Lines of descent in the deterministic mutation-selection model with pairwise interaction

zbMATH Keywords

population geneticsdualityinteractive particle systemancestral selection-recombination graphMoran model with selection and recombinationselection-recombination differential equation

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15) Random graphs (graph-theoretic aspects) (05C80) Continuous-time Markov processes on general state spaces (60J25) Combinatorial probability (60C05)

Cites Work

• Probability Models for DNA Sequence Evolution
• Title not available (Why is that?)
• Markov Chains
• Title not available (Why is that?)
• The concept of duality and applications to Markov processes arising in neutral population genetics models
• ON A CLASS OF SKEW DISTRIBUTION FUNCTIONS
• Continuous time Markov processes. An introduction.
• Title not available (Why is that?)
• On the notion(s) of duality for Markov processes
• Ancestral processes with selection
• Genealogical processes for Fleming-Viot models with selection and recombination
• Properties of a neutral allele model with intragenic recombination
• The general recombination equation in continuous time and its solution
• Closed-form asymptotic sampling distributions under the coalescent with recombination for an arbitrary number of loci
• Partitioning, duality, and linkage disequilibria in the Moran model with recombination
• Title not available (Why is that?)
• Title not available (Why is that?)
• An Exactly Solved Model for Mutation, Recombination and Selection
• The common ancestor type distribution of a \(\Lambda\)-Wright-Fisher process with selection and mutation
• Common ancestor type distribution: a Moran model and its deterministic limit
• The selection mutation equation
• Effect of epistasis and linkage on fixation probability in three-locus models: an ancestral recombination-selection graph approach
• Ancestral processes for non-neutral models of complex diseases
• Title not available (Why is that?)
• Probabilistic structures in evolution
• Cycling in simple genetic systems
• Convergence of multilocus systems under weak epistasis or weak selection
• Title not available (Why is that?)
• Stable cycling in discrete-time genetic models.
• Title not available (Why is that?)
• Haldane linearisation done right: solving the nonlinear recombination equation the easy way
• Haldane Linearisation of Baric Algebras
• General two-locus selection models: Some objectives, results and interpretations
• Multilocus dynamics under haploid selection
• The deterministic limit of the Moran model: a uniform central limit theorem
• A probabilistic view on the deterministic mutation-selection equation: dynamics, equilibria, and ancestry via individual lines of descent
• Duality and cones of Markov processes and their semigroups
• Evolutionary dynamics in the two-locus two-allele model with weak selection
• The fixation probability and time for a doubly beneficial mutant
• Lines of descent under selection
• Tractable diffusion and coalescent processes for weakly correlated loci
• Chromosome painting: how recombination mixes ancestral colors

Cited In (8)

• Labeled partitions in action: recombination, selection, mutation and more
• Solving the migration-recombination equation from a genealogical point of view
• Selection, recombination, and the ancestral initiation graph
• Mutation and recombination with tight linkage
• Asymptotic sampling distributions made easy: loose linkage in the ancestral recombination graph
• Evolution with recombination as Gibbs sampling
• The recombination equation for interval partitions
• A probabilistic view on the deterministic mutation-selection equation: dynamics, equilibria, and ancestry via individual lines of descent

This page was built for publication: Solving the selection-recombination equation: ancestral lines and dual processes

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2035567)