An Exactly Solved Model for Mutation, Recombination and Selection

DOI10.4153/CJM-2003-001-0MaRDI QIDQ4808089zbMATH OpenOpenAlexFDO

Authors Michael Baake, Ellen Baake

Publication date 2003

Published in Canadian Journal of Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0210422

zbMATH Keywords

nonlinear ODEsmeasure-valued dynamical systemsMöbius inversion

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15) Dynamical systems in biology (37N25) Markov processes (60J99) Combinatorics of partially ordered sets (06A07) Nonlinear ordinary differential operators (34L30) Random dynamical systems (37H99)

Abstract: It is well known that rather general mutation-recombination models can be solved algorithmically (though not in closed form) by means of Haldane linearization. The price to be paid is that one has to work with a multiple tensor product of the state space one started from. Here, we present a relevant subclass of such models, in continuous time, with independent mutation events at the sites, and crossover events between them. It admits a closed solution of the corresponding differential equation on the basis of the original state space, and also closed expressions for the linkage disequilibria, derived by means of M"obius inversion. As an extra benefit, the approach can be extended to a model with selection of additive type across sites. We also derive a necessary and sufficient criterion for the mean fitness to be a Lyapunov function and determine the asymptotic behaviour of the solutions.

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Cited in

(27)

• Moment closure in a Moran model with recombination
• Mutation and recombination in a model of phenotype evolution
• Critical population and error threshold on the sharp peak landscape for a Moran model
• A Mutation-Selection Model with Recombination for General Genotypes
• Solving the migration-recombination equation from a genealogical point of view
• Labeled partitions in action: recombination, selection, mutation and more
• Partitioning, duality, and linkage disequilibria in the Moran model with recombination
• Addendum to: ``Recombination semigroups on measure spaces
• Single-crossover recombination in discrete time
• Solving the selection-recombination equation: ancestral lines and dual processes
• Exact solutions for the selection-mutation equilibrium in the Crow-Kimura evolutionary model
• Single-crossover dynamics: finite versus infinite populations
• An exactly solvable model of random site-specific recombinations
• Mutation and recombination with tight linkage
• Asymptotic sampling distributions made easy: loose linkage in the ancestral recombination graph
• Erratum to: An Exactly Solved Model for Recombination, Mutation and Selection
• Mutation-selection balance with recombination: convergence to equilibrium for polynomial selection costs
• A basic model of mutations
• Genetic recombination as a generalised gradient flow
• Evolution with recombination as Gibbs sampling
• The recombination equation for interval partitions
• Freely forming groups: Trying to be rare
• Single-crossover recombination and ancestral recombination trees
• The general recombination equation in continuous time and its solution
• A mutation-selection-recombination model in population genetics
• Recombination semigroups on measure spaces
• Haldane linearisation done right: solving the nonlinear recombination equation the easy way

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