Single-crossover recombination and ancestral recombination trees

DOI10.1007/S00285-013-0662-XMaRDI QIDQ2447556zbMATH OpenOpenAlexWikidataFDO

Authors Ellen Baake, Ute von Wangenheim

Publication date 28 April 2014

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1206.0950

zbMATH Keywords

ancestral treespopulation geneticssegmentation processessubtree decompositions

Mathematics Subject Classification ID

Strong limit theorems (60F15) Applications of continuous-time Markov processes on discrete state spaces (60J28) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We consider the Wright-Fisher model for a population of $N$ individuals, each identified with a sequence of a finite number of sites, and single-crossover recombination between them. We trace back the ancestry of single individuals from the present population. In the $Noinfty$ limit without rescaling of parameters or time, this ancestral process is described by a random tree, whose branching events correspond to the splitting of the sequence due to recombination. With the help of a decomposition of the trees into subtrees, we calculate the probabilities of the topologies of the ancestral trees. At the same time, these probabilities lead to a semi-explicit solution of the deterministic single-crossover equation. The latter is a discrete-time dynamical system that emerges from the Wright-Fisher model via a law of large numbers and has been waiting for a solution for many decades.

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Cited in

(9)

• The time to the ancestor along sequences with recombination
• The geometry of recombination
• Corrigendum to: ``A probabilistic analysis of a discrete-time evolution in recombination
• A probabilistic analysis of a discrete-time evolution in recombination
• The general recombination equation in continuous time and its solution
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• Deterministic and stochastic aspects of single-crossover recombination
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