Selection, recombination, and the ancestral initiation graph

DOI10.1016/J.TPB.2021.08.001zbMATH Open1482.92053arXiv2101.10080OpenAlexW3200058726MaRDI QIDQ2076089FDOQ2076089

Authors: Frederic Alberti, C. Herrmann, Ellen Baake 

Publication date: 18 February 2022

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: Recently, the selection-recombination equation with a single selected site and an arbitrary number of neutral sites was solved by means of the ancestral selection-recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection-recombination equation. We apply our method to systematically explain a long-standing observation concerning the dynamics of linkage disequilibrium between two neutral loci hitchhiking along with a selected one. In particular, this clarifies the nontrivial dependence on the position of the selected site.

Full work available at URL: https://arxiv.org/abs/2101.10080

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zbMATH Keywords

population geneticslinkage disequilibriumhitchhikingselection-recombination differential equationancestral initiation graph

Mathematics Subject Classification ID

Problems related to evolution (92D15)

Cites Work

• Erratum to: An Exactly Solved Model for Recombination, Mutation and Selection
• On the Probability Theory of Linkage in Mendelian Heredity
• Ancestral processes with selection
• Genealogical processes for Fleming-Viot models with selection and recombination
• Properties of a neutral allele model with intragenic recombination
• Title not available (Why is that?)
• Probabilistic structures in evolution
• Title not available (Why is that?)
• Haldane linearisation done right: solving the nonlinear recombination equation the easy way
• Numerical Methods for Ordinary Differential Equations
• Solving the selection-recombination equation: ancestral lines and dual processes

Cited In (9)

• Title not available (Why is that?)
• Labeled partitions in action: recombination, selection, mutation and more
• Ancestral recombination graphs under non-random ascertainment, with applications to gene mapping
• More on selection for and against recombination
• Asymptotic sampling distributions made easy: loose linkage in the ancestral recombination graph
• Evolution with recombination as Gibbs sampling
• Single-crossover recombination and ancestral recombination trees
• The time to the ancestor along sequences with recombination
• On the Height and Length of the Ancestral Recombination Graph

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