Evolution with recombination as Gibbs sampling

DOI10.1016/J.TPB.2023.03.005MaRDI QIDQ6106334zbMATH OpenOpenAlexFDO

Authors Jenny M. Poulton, Lee Altenberg, Chris Watkins

Publication date 27 June 2023

Published in Theoretical Population Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2211.05032

zbMATH Keywords

detailed balanceDirichlet processgenetic architectureMoran process

Mathematics Subject Classification ID

Biology and other natural sciences (92-XX)

Abstract: This work presents a population genetic model of evolution, which includes haploid selection, mutation, recombination, and drift. The mutation-selection equilibrium can be expressed exactly in closed form for arbitrary fitness functions without resorting to diffusion approximations. Tractability is achieved by generating new offspring using n-parent rather than 2-parent recombination. While this enforces linkage equilibrium among offspring, it allows analysis of the whole population under linkage disequilibrium. We derive a general and exact relationship between fitness fluctuations and response to selection. Our assumptions allow analytical calculation of the stationary distribution of the model for a variety of non-trivial fitness functions. These results allow us to speak to genetic architecture, i.e., what stationary distributions result from different fitness functions. This paper presents methods for exactly deriving stationary states for finite and infinite populations. This method can be applied to many fitness functions, and we give exact calculations for four of these. These results allow us to investigate metastability, tradeoffs between fitness functions, and even consider error-correcting codes

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