Quasi-equilibria and click times for a variant of Muller's ratchet

DOI10.1214/23-EJP1055zbMATH Open1528.60096arXiv2211.13109MaRDI QIDQ6136826FDOQ6136826

Authors: Adrián González Casanova, Charline Smadi, Anton Wakolbinger 

Publication date: 17 January 2024

Published in: Electronic Journal of Probability (Search for Journal in Brave)

Abstract: Consider a population of $N$ individuals, each of them carrying a type in $mathbb{N}_0$. The population evolves according to a Moran dynamics with selection and mutation, where an individual of type $k$ has the same selective advantage over all individuals with type $k^{\prime }>k$, and type $k$ mutates to type $k+1$ at a constant rate. This model is thus a variation of the classical Muller's ratchet: there the selective advantage is proportional to $k^{\prime }-k$. For a regime of selection strength and mutation rates which is between the regimes of weak and strong selection/mutation, we obtain the asymptotic rate of the {em click times} of the ratchet (i.e. the times at which the hitherto minimal (`best') type in the population is lost), and reveal the quasi-stationary type frequency profile between clicks. The large population limit of this profile is characterized as the normalized attractor of a ``dual hierarchical multitype logistic system, and also via the distribution of the final minimal displacement in a branching random walk with one-sided steps. An important role in the proofs is played by a graphical representation of the model, both forward and backward in time, and a central tool is the ancestral selection graph decorated by mutations.

Full work available at URL: https://arxiv.org/abs/2211.13109

zbMATH Keywords

dualityfirst passage percolationquasi-equilibriumancestral selection graphMuller's ratchettournament selectionclick rateHarris graphical representation

Mathematics Subject Classification ID

Problems related to evolution (92D15) Interacting random processes; statistical mechanics type models; percolation theory (60K35)

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