Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10) Computational methods for stochastic equations (aspects of stochastic analysis) (60H35) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Interacting random processes; statistical mechanics type models; percolation theory (60K35) Problems related to evolution (92D15)
Abstract: We consider an infinite-dimensional system of stochastic differential equations describing the evolution of type frequencies in a large population. The type of an individual is the number of deleterious mutations it carries, where fitness of individuals carrying k mutations is decreased by alpha k for some alpha>0. Along the individual lines of descent, new mutations accumulate at rate lambda per generation, and each of these mutations has a probability gamma per generation to disappear. While the case gamma=0 is known as (the Fleming-Viot version of) Muller's ratchet, the case gamma>0 is associated with compensatory mutations in the biological literature. We show that the system has a unique weak solution. In the absence of random fluctuations in type frequencies (i.e., for the so-called infinite population limit) we obtain the solution in a closed form by analyzing a probabilistic particle system and show that for gamma>0, the unique equilibrium state is the Poisson distribution with parameter lambda/(gamma+alpha).
Recommendations
- How often does the ratchet click? Facts, heuristics, asymptotics
- Muller's ratchet clicks in finite time
- The accumulation of mutations in asexual populations and the structure of genealogical trees in the presence of selection
- Two linked loci under mutation-selection balance and Muller's ratchet
- Rigorous results for a population model with selection. I: Evolution of the fitness distribution
Cites work
- A Fleming-Viot process with unbounded selection
- Analytical solution of the evolution dynamics on a multiplicative-fitness landscape
- Asymptotic behavior of the rate of adaptation
- Fleming–Viot Processes in Population Genetics
- How often does the ratchet click? Facts, heuristics, asymptotics
- scientific article; zbMATH DE number 1713116 (Why is no real title available?)
- scientific article; zbMATH DE number 446474 (Why is no real title available?)
- scientific article; zbMATH DE number 3951715 (Why is no real title available?)
- scientific article; zbMATH DE number 2006037 (Why is no real title available?)
- Infinite dimensional stochastic differential equations and their applications
- Muller's ratchet clicks in finite time
- On minimax estimation of a sparse normal mean vector
- Stochastic Equations in Infinite Dimensions
- Stochastic equations, flows and measure-valued processes
- The accumulation of deleterious genes in a population - Muller's Ratchet
- The accumulation of mutations in asexual populations and the structure of genealogical trees in the presence of selection
Cited in
(11)- The accumulation of mutations in asexual populations and the structure of genealogical trees in the presence of selection
- Two linked loci under mutation-selection balance and Muller's ratchet
- Models of compensatory molecular evolution: effects of back mutation
- Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
- Muller's ratchet clicks in finite time
- Quasi-equilibria and click times for a variant of Muller's ratchet
- Mutational meltdown in asexual populations doomed to extinction
- Compensatory evolution in diploid populations
- Metastability between the clicks of Muller's ratchet
- Muller's ratchet in a near-critical regime: tournament versus fitness proportional selection
- Degenerate convergence of semigroups related to a model of stochastic gene expression
This page was built for publication: Muller's ratchet with compensatory mutations
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q691118)
