The accumulation of deleterious genes in a population - Muller's Ratchet
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Cites work
- Coherent random walks arising in some genetical models
- Evolution in finite populations with infinitely many types
- Evolution processes with continuity of types
- Limit theorems for some stochastic evolution models
- On evolution in a population with an infinite number of types
- Wandering distributions and the electrophoretic profile
Cited in
(44)- The effect of the reproductive system on mutation load
- Sexual recombination under the joint effects of mutation, selection, and random sampling drift
- The dynamics of infinitesimally rare alleles, applied to the evolution of mutation rates and the expression of deleterious mutations
- What is the difference between models of error thresholds and Muller's ratchet?
- The optimum recombination rate that realizes the fastest evolution of a novel functional combination of many genes
- Multi-site adaptation in the presence of infrequent recombination
- A stochastic model for a single click of Muller's ratchet
- Fixation probability of a nonmutator in a large population of asexual mutators
- Package models and the information crisis of prebiotic evolution
- Fixation probabilities of additive alleles in diploid populations
- Deterministic evolution of an asexual population under the action of beneficial and deleterious mutations on additive fitness landscapes
- Limiting fitness distributions in evolutionary dynamics
- Fifty years of theoretical population biology
- Haigh (1978) and Muller's ratchet
- A stochastic model for the mutation-selection balance in an infinite asexual population with a genome of fixed size
- Effect of selection on the topology of genealogical trees
- Within-host evolution and virulence in microparasites
- The structure of allelic diversity in the presence of purifying selection
- Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
- A generalized model of mutation-selection balance with applications to aging
- Generation of variation and a modified mean fitness principle: necessity is the mother of genetic invention
- Muller's ratchet clicks in finite time
- The spatial Muller's ratchet: surfing of deleterious mutations during range expansion
- Diffusion approximations in population genetics and the rate of Muller's ratchet
- Role of epistasis on the fixation probability of a non-mutator in an adapted asexual population
- Critical fitness collapse in three-dimensional spatial population genetics
- Upper bound on the rate of adaptation in an asexual population
- Competing islands limit the rate of adaptation in structured populations
- Absolute negative mobility in evolution
- The effect of recombination on the speed of evolution
- Life history and deleterious mutation rate coevolution
- Quasi-equilibria and click times for a variant of Muller's ratchet
- Mutational meltdown in asexual populations doomed to extinction
- The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
- Modeling propagation of weakly advantageous mutations in cancer cells
- Muller's ratchet and gene duplication
- Muller's ratchet with compensatory mutations
- Metastability between the clicks of Muller's ratchet
- Muller's ratchet in a near-critical regime: tournament versus fitness proportional selection
- Limits to selection on standing variation in an asexual population
- Fisher information limits on genetic stability, diversity, and regulation
- Fluctuations in fitness distributions and the effects of weak linked selection on sequence evolution
- Highly fit ancestors of a partly sexual haploid population
- Asymptotic behavior of the rate of adaptation
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