The accumulation of deleterious genes in a population - Muller's Ratchet

DOI10.1016/0040-5809(78)90027-8MaRDI QIDQ754110zbMATH OpenOpenAlexWikidataFDO

Authors John Haigh

Publication date 1978

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0040-5809(78)90027-8

zbMATH Keywords

Poisson distributionequilibrium stateWright-Fisher modelMuller's ratchetaccumulation of deleterious genesasexually reproducing population

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Population dynamics (general) (92D25)

Cites work

• Coherent random walks arising in some genetical models
• Evolution in finite populations with infinitely many types
• Evolution processes with continuity of types
• Limit theorems for some stochastic evolution models
• On evolution in a population with an infinite number of types
• Wandering distributions and the electrophoretic profile

Cited in

(38)

• Fixation probability of a nonmutator in a large population of asexual mutators
• Muller's ratchet with compensatory mutations
• Quasi-equilibria and click times for a variant of Muller's ratchet
• The effect of the reproductive system on mutation load
• The effect of recombination on the speed of evolution
• Limiting fitness distributions in evolutionary dynamics
• Fixation probabilities of additive alleles in diploid populations
• Mutational meltdown in asexual populations doomed to extinction
• Generation of variation and a modified mean fitness principle: necessity is the mother of genetic invention
• Package models and the information crisis of prebiotic evolution
• A generalized model of mutation-selection balance with applications to aging
• A stochastic model for the mutation-selection balance in an infinite asexual population with a genome of fixed size
• Critical fitness collapse in three-dimensional spatial population genetics
• The dynamics of infinitesimally rare alleles, applied to the evolution of mutation rates and the expression of deleterious mutations
• Absolute negative mobility in evolution
• Role of epistasis on the fixation probability of a non-mutator in an adapted asexual population
• Within-host evolution and virulence in microparasites
• Competing islands limit the rate of adaptation in structured populations
• Muller's ratchet clicks in finite time
• Highly fit ancestors of a partly sexual haploid population
• Fluctuations in fitness distributions and the effects of weak linked selection on sequence evolution
• The spatial Muller's ratchet: surfing of deleterious mutations during range expansion
• Sexual recombination under the joint effects of mutation, selection, and random sampling drift
• Multi-site adaptation in the presence of infrequent recombination
• What is the difference between models of error thresholds and Muller's ratchet?
• Fifty years of theoretical population biology
• A stochastic model for a single click of Muller's ratchet
• The structure of allelic diversity in the presence of purifying selection
• Deterministic evolution of an asexual population under the action of beneficial and deleterious mutations on additive fitness landscapes
• Upper bound on the rate of adaptation in an asexual population
• Haigh (1978) and Muller's ratchet
• Effect of selection on the topology of genealogical trees
• The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
• Life history and deleterious mutation rate coevolution
• Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
• The optimum recombination rate that realizes the fastest evolution of a novel functional combination of many genes
• Asymptotic behavior of the rate of adaptation
• Diffusion approximations in population genetics and the rate of Muller's ratchet

This page was built for publication: The accumulation of deleterious genes in a population - Muller's Ratchet

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q754110)