The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation

DOI10.1016/J.TPB.2007.10.004zbMATH Open1202.92066arXiv0707.3469OpenAlexW2053731023WikidataQ41853709 ScholiaQ41853709MaRDI QIDQ615387FDOQ615387

Igor M. Rouzine, Éric Brunet, Claus O. Wilke

Publication date: 5 January 2011

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: We use traveling-wave theory to derive expressions for the rate of accumulation of deleterious mutations under Muller's ratchet and the speed of adaptation under positive selection in asexual populations. Traveling-wave theory is a semi-deterministic description of an evolving population, where the bulk of the population is modeled using deterministic equations, but the class of the highest-fitness genotypes, whose evolution over time determines loss or gain of fitness in the population, is given proper stochastic treatment. We derive improved methods to model the highest-fitness class (the stochastic edge) for both Muller's ratchet and adaptive evolution, and calculate analytic correction terms that compensate for inaccuracies which arise when treating discrete fitness classes as a continuum. We show that traveling wave theory makes excellent predictions for the rate of mutation accumulation in the case of Muller's ratchet, and makes good predictions for the speed of adaptation in a very broad parameter range. We predict the adaptation rate to grow logarithmically in the population size until the population size is extremely large.

Full work available at URL: https://arxiv.org/abs/0707.3469

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zbMATH Keywords

adaptationevolutionstochastictraveling wavefitnesssolitaryasexualmulti-locussemi-deterministic

Mathematics Subject Classification ID

Problems related to evolution (92D15) Dynamical systems in biology (37N25) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cites Work

• Mathematical population genetics. I: Theoretical introduction.
• A simple stochastic gene substitution model
• Evolution on a smooth landscape
• Some non-standard problems in viscous flow
• Diffusion models in population genetics
• The accumulation of deleterious genes in a population - Muller's Ratchet
• The accumulation of mutations in asexual populations and the structure of genealogical trees in the presence of selection

Cited In (30)

• Genealogies in simple models of evolution
• Rapid adaptation in large populations with very rare sex: scalings and spontaneous oscillations
• Evolutionary branching via replicator-mutator equations
• Mutational meltdown in asexual populations doomed to extinction
• Explicit solutions in evolutionary genetics and applications
• Evolution of molecular phenotypes under stabilizing selection
• Model with two types of CTL regulation and experiments on CTL dynamics
• The quantitative theory of within-host viral evolution
• The calculation of mean first arrival time for double mutants, crossing the fitness valley
• A Gaussian particle distribution for branching Brownian motion with an inhomogeneous branching rate
• Absolute negative mobility in evolution
• Fluctuations in fitness distributions and the effects of weak linked selection on sequence evolution
• Probabilistic analysis of replicator–mutator equations
• The speed of evolution in large asexual populations
• Statistical questions in experimental evolution
• Population dynamics and statistical physics in synergy. Abstracts from the workshop held March 6--12, 2022
• Multi-site adaptation in the presence of infrequent recombination
• A stochastic model for a single click of Muller's ratchet
• Asexual evolution waves: fluctuations and universality
• Deterministic evolution of an asexual population under the action of beneficial and deleterious mutations on additive fitness landscapes
• Upper bound on the rate of adaptation in an asexual population
• Traveling waves of selective sweeps
• The Effect of Recombination on the Speed of Evolution
• Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
• Speed of evolution in large asexual populations with diminishing returns
• Asymptotic behavior of the rate of adaptation
• Diffusion approximations in population genetics and the rate of Muller's ratchet
• Title not available (Why is that?)
• A model with Darwinian dynamics on a rugged landscape
• The fixation probability of two competing beneficial mutations

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