Evolution of molecular phenotypes under stabilizing selection
From MaRDI portal
Publication:3301404
DOI10.1088/1742-5468/2013/01/P01012zbMATH Open1456.92100arXiv1301.3981OpenAlexW3105540032MaRDI QIDQ3301404FDOQ3301404
Stephan Schiffels, Michael Lässig, Armita Nourmohammad
Publication date: 11 August 2020
Published in: Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)
Abstract: Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution builds on genome evolution in a complicated way, which involves selection, genetic drift, mutations and recombination. Here we develop a coarse-grained evolutionary statistics for phenotypes, which decouples from details of the underlying genotypes. We derive approximate evolution equations for the distribution of phenotype values within and across populations. This dynamics covers evolutionary processes at high and low recombination rates, that is, it applies to sexual and asexual populations. In a fitness landscape with a single optimal phenotype value, the phenotypic diversity within populations and the divergence between populations reach evolutionary equilibria, which describe stabilizing selection. We compute the equilibrium distributions of both quantities analytically and we show that the ratio of mean divergence and diversity depends on the strength of selection in a universal way: it is largely independent of the phenotype's genomic encoding and of the recombination rate. This establishes a new method for the inference of selection on molecular phenotypes beyond the genome level. We discuss the implications of our findings for the predictability of evolutionary processes.
Full work available at URL: https://arxiv.org/abs/1301.3981
Recommendations
- Adaptive evolution of molecular phenotypes
- Cryptic selection forces and dynamic heritability in generalized phenotypic evolution
- scientific article; zbMATH DE number 1532288
- Dynamics of a quantitative character subject only to stabilising selection
- Evolutionary and convergence stability for continuous phenotypes in finite populations derived from two-allele models
Cites Work
- Mathematical population genetics. I: Theoretical introduction.
- Handbook of stochastic methods for physics, chemistry and the natural sciences.
- On the application of statistical physics to evolutionary biology
- Diffusion models in population genetics
- The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
- Emergence of clones in sexual populations
- Moments, cumulants, and polygenic dynamics
Cited In (10)
- Evolutionarily rational mutations in structured populations
- The role of population size in molecular evolution
- Title not available (Why is that?)
- Adaptive evolution of molecular phenotypes
- Inferring epistasis from genomic data with comparable mutation and outcrossing rate
- Towards a unified theory of molecular evolution (TME)
- Quantitative immunology for physicists
- Title not available (Why is that?)
- Title not available (Why is that?)
- Cryptic selection forces and dynamic heritability in generalized phenotypic evolution
This page was built for publication: Evolution of molecular phenotypes under stabilizing selection
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3301404)
