Emergence of clones in sexual populations

DOI10.1088/1742-5468/2013/01/P01008zbMATH Open1456.92089arXiv1205.2059OpenAlexW2039147728WikidataQ59712509 ScholiaQ59712509MaRDI QIDQ3301397FDOQ3301397

Richard A. Neher, Mark Mezard, Boris I. Shraiman, Marija Vucelja

Publication date: 11 August 2020

Published in: Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Abstract: In sexual population, recombination reshuffles genetic variation and produces novel combinations of existing alleles, while selection amplifies the fittest genotypes in the population. If recombination is more rapid than selection, populations consist of a diverse mixture of many genotypes, as is observed in many populations. In the opposite regime, which is realized for example in the facultatively sexual populations that outcross in only a fraction of reproductive cycles, selection can amplify individual genotypes into large clones. Such clones emerge when the fitness advantage of some of the genotypes is large enough that they grow to a significant fraction of the population despite being broken down by recombination. The occurrence of this "clonal condensation" depends, in addition to the outcrossing rate, on the heritability of fitness. Clonal condensation leads to a strong genetic heterogeneity of the population which is not adequately described by traditional population genetics measures, such as Linkage Disequilibrium. Here we point out the similarity between clonal condensation and the freezing transition in the Random Energy Model of spin glasses. Guided by this analogy we explicitly calculate the probability, Y, that two individuals are genetically identical as a function of the key parameters of the model. While Y is the analog of the spin-glass order parameter, it is also closely related to rate of coalescence in population genetics: Two individuals that are part of the same clone have a recent common ancestor.

Full work available at URL: https://arxiv.org/abs/1205.2059

Mathematics Subject Classification ID

Genetics and epigenetics (92D10)

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Cited In (3)

• Evolution of molecular phenotypes under stabilizing selection
• Adaptive evolution of molecular phenotypes
• A model with Darwinian dynamics on a rugged landscape

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