Asexual evolution waves: fluctuations and universality

DOI10.1088/1742-5468/2013/01/P01011zbMATH Open1456.92114arXiv1210.6295OpenAlexW3106484101MaRDI QIDQ3301401FDOQ3301401

Authors:

Publication date: 11 August 2020

Published in: Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Abstract: In large asexual populations, multiple beneficial mutations arise in the population, compete, interfere with each other, and accumulate on the same genome, before any of them fix. The resulting dynamics, although studied by many authors, is still not fully understood, fundamentally because the effects of fluctuations due to the small numbers of the fittest individuals are large even in enormous populations. In this paper, branching processes and various asymptotic methods for analyzing the stochastic dynamics are further developed and used to obtain information on fluctuations, time dependence, and the distributions of sizes of subpopulations, jumps in the mean fitness, and other properties. The focus is on the behavior of a broad class of models: those with a distribution of selective advantages of available beneficial mutations that falls off more rapidly than exponentially. For such distributions, many aspects of the dynamics are universal - quantitatively so for extremely large populations. On the most important time scale that controls coalescent properties and fluctuations of the speed, the dynamics is reduced to a simple stochastic model that couples the peak and the high-fitness "nose" of the fitness distribution. Extensions to other models and distributions of available mutations are discussed briefly.

Full work available at URL: https://arxiv.org/abs/1210.6295

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Mathematics Subject Classification ID

Problems related to evolution (92D15) Population dynamics (general) (92D25)

Cites Work

• The speed of evolution in large asexual populations
• The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
• The rate at which asexual populations cross fitness valleys
• Asymptotic behavior of the rate of adaptation
• Quasi-stationary regime of a branching random walk in presence of an absorbing wall

Cited In (14)

• Rapid adaptation in large populations with very rare sex: scalings and spontaneous oscillations
• Limiting fitness distributions in evolutionary dynamics
• The more the merrier? Entropy and statistics of asexual reproduction in freshwater planarians
• Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics
• A Gaussian particle distribution for branching Brownian motion with an inhomogeneous branching rate
• Branching with selection and mutation. I: Mutant fitness of Fréchet type
• Highly fit ancestors of a partly sexual haploid population
• Fluctuations in fitness distributions and the effects of weak linked selection on sequence evolution
• The speed of evolution in large asexual populations
• Population dynamics and statistical physics in synergy. Abstracts from the workshop held March 6--12, 2022
• Haigh (1978) and Muller's ratchet
• The Effect of Recombination on the Speed of Evolution
• The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
• Title not available (Why is that?)

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