Deterministic evolution of an asexual population under the action of beneficial and deleterious mutations on additive fitness landscapes

DOI10.1016/J.TPB.2016.08.009MaRDI QIDQ2011548zbMATH OpenOpenAlexWikidataFDO

Authors Kavita Jain, Sona John

Publication date 4 August 2017

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1604.03676

zbMATH Keywords

mutation-selection balanceexact resultsbeneficial mutations

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We study a continuous time model for the frequency distribution of an infinitely large asexual population in which both beneficial and deleterious mutations occur and the fitness is additive. When beneficial mutations are ignored, the exact solution for the frequency distribution is known to be a Poisson distribution. Here we include beneficial mutations and obtain exact expressions for the frequency distribution at all times using an eigenfunction expansion method. We find that the stationary distribution is non-Poissonian and related to the Bessel function of the first kind. We also provide suitable approximations for the stationary distribution and the time to relax to the steady state. Our exact results, especially at mutation-selection equilibrium, can be useful in developing semi-deterministic approaches to understand stochastic evolution.

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Cites work

• scientific article; zbMATH DE number 3806623 (Why is no real title available?)
• scientific article; zbMATH DE number 3273551 (Why is no real title available?)
• scientific article; zbMATH DE number 3081828 (Why is no real title available?)
• Analytical solution of the evolution dynamics on a multiplicative-fitness landscape
• Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
• Evolution on a smooth landscape
• How often does the ratchet click? Facts, heuristics, asymptotics
• Nonlinear deterministic equations in biological evolution
• On Eigen's theory of the self-organization of matter and the evolution of biological macromolecules
• Solutions to the discrete Airy equation: application to parabolic equation calculations
• The accumulation of deleterious genes in a population - Muller's Ratchet
• The speed of evolution in large asexual populations
• The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation

Cited in

(5)

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• Analytical solution of the evolution dynamics on a multiplicative-fitness landscape
• Evolutionary dynamics of a quantitative trait in a finite asexual population
• The dynamical way to mutation-selection balance of an infinite population evolving on a truncated fitness landscape
• Asexual evolution waves: fluctuations and universality

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