Deterministic evolution of an asexual population under the action of beneficial and deleterious mutations on additive fitness landscapes

DOI10.1016/J.TPB.2016.08.009zbMATH Open1367.92084arXiv1604.03676OpenAlexW2963685481WikidataQ51813954 ScholiaQ51813954MaRDI QIDQ2011548FDOQ2011548

Authors: Kavita Jain, Sona John 

Publication date: 4 August 2017

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: We study a continuous time model for the frequency distribution of an infinitely large asexual population in which both beneficial and deleterious mutations occur and the fitness is additive. When beneficial mutations are ignored, the exact solution for the frequency distribution is known to be a Poisson distribution. Here we include beneficial mutations and obtain exact expressions for the frequency distribution at all times using an eigenfunction expansion method. We find that the stationary distribution is non-Poissonian and related to the Bessel function of the first kind. We also provide suitable approximations for the stationary distribution and the time to relax to the steady state. Our exact results, especially at mutation-selection equilibrium, can be useful in developing semi-deterministic approaches to understand stochastic evolution.

Full work available at URL: https://arxiv.org/abs/1604.03676

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zbMATH Keywords

mutation-selection balanceexact resultsbeneficial mutations

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

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Cited In (5)

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• Analytical solution of the evolution dynamics on a multiplicative-fitness landscape
• Evolutionary dynamics of a quantitative trait in a finite asexual population
• The dynamical way to mutation-selection balance of an infinite population evolving on a truncated fitness landscape
• Asexual evolution waves: fluctuations and universality

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