Critical fitness collapse in three-dimensional spatial population genetics

DOI10.1088/1742-5468/2015/05/P05027zbMATH Open1456.92088arXiv1504.00748MaRDI QIDQ3302255FDOQ3302255

Authors: Maxim Lavrentovich 

Publication date: 11 August 2020

Published in: Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Abstract: If deleterious mutations near a fitness maximum in a spatially distributed population are sufficiently frequent or detrimental, the population can undergo a fitness collapse, similarly to the Muller's ratchet effect in well-mixed populations. Recent studies of one-dimensional habitats (e.g., the frontier of a two-dimensional range expansion) have shown that the onset of the fitness collapse is described by a directed percolation phase transition with its associated critical exponents. We consider population fitness collapse in three-dimensional range expansions with both inflating and fixed-size frontiers (applicable to, e.g., expanding and treadmilling spherical tumors, respectively). We find that the onset of fitness collapse in these two cases obeys different scaling laws, and that competition between species at the frontier leads to a deviation from directed percolation scaling. As in two-dimensional range expansions, inflating frontiers modify the critical behavior by causally disconnecting well-separated portions of the population.

Full work available at URL: https://arxiv.org/abs/1504.00748

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Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Time-dependent percolation in statistical mechanics (82C43)

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Cited In (3)

• Point to point continuum percolation in two dimensions
• The spatial Muller's ratchet: surfing of deleterious mutations during range expansion
• Survival probabilities at spherical frontiers

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