Critical fitness collapse in three-dimensional spatial population genetics

DOI10.1088/1742-5468/2015/05/P05027MaRDI QIDQ3302255zbMATH OpenFDO

Authors Maxim Lavrentovich

Publication date 11 August 2020

Published in Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1504.00748

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Time-dependent percolation in statistical mechanics (82C43)

Abstract: If deleterious mutations near a fitness maximum in a spatially distributed population are sufficiently frequent or detrimental, the population can undergo a fitness collapse, similarly to the Muller's ratchet effect in well-mixed populations. Recent studies of one-dimensional habitats (e.g., the frontier of a two-dimensional range expansion) have shown that the onset of the fitness collapse is described by a directed percolation phase transition with its associated critical exponents. We consider population fitness collapse in three-dimensional range expansions with both inflating and fixed-size frontiers (applicable to, e.g., expanding and treadmilling spherical tumors, respectively). We find that the onset of fitness collapse in these two cases obeys different scaling laws, and that competition between species at the frontier leads to a deviation from directed percolation scaling. As in two-dimensional range expansions, inflating frontiers modify the critical behavior by causally disconnecting well-separated portions of the population.

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Cited in

(3)

• The spatial Muller's ratchet: surfing of deleterious mutations during range expansion
• Point to point continuum percolation in two dimensions
• Survival probabilities at spherical frontiers

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