Stability and Hopf bifurcation in a mathematical model of pluripotent stem cell dynamics

DOI10.1016/J.NONRWA.2004.12.010MaRDI QIDQ2572089zbMATH OpenOpenAlexFDO

Authors Fabien Crauste, Shigui Ruan, Mostafa Adimy

Publication date 14 November 2005

Published in Nonlinear Analysis. Real World Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0904.2491

zbMATH Keywords

Hopf bifurcationStabilityDelay differential equationsStem cellsBlood production system

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Physiology (general) (92C30) Stability theory of functional-differential equations (34K20) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Cell biology (92C37) Bifurcation theory of functional-differential equations (34K18)

Abstract: We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell cycle duration and is uniformly distributed on an interval. We obtain stability conditions independent of the delay. We also show that the distributed delay can destabilize the entire system. In particularly, it is shown that Hopf bifurcations can occur.

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(45)

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• DISCRETE-MATURITY STRUCTURED MODEL OF CELL DIFFERENTIATION WITH APPLICATIONS TO ACUTE MYELOGENOUS LEUKEMIA
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• Blood cell dynamics: half of a century of modelling
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• A mathematical model of stem cell regeneration with epigenetic state transitions
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• Mathematical model of hematopoiesis dynamics with growth factor-dependent apoptosis and proliferation regulations
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• Amplitude and phase dynamics in oscillators with distributed-delay coupling

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