Giant number fluctuations in microbial ecologies

DOI10.1016/J.JTBI.2012.05.030MaRDI QIDQ2632047zbMATH OpenOpenAlexWikidataFDO

Authors Dipjyoti Das, Dibyendu Das, Ashok Prasad

Publication date 14 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1206.5904

zbMATH Keywords

horizontal gene transferlysis-lysogenymutationpopulation dynamicsstochastic growth

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Ecology (92D40)

Abstract: Statistical fluctuations in population sizes of microbes may be quite large depending on the nature of their underlying stochastic dynamics. For example, the variance of the population size of a microbe undergoing a pure birth process with unlimited resources is proportional to the square of its mean. We refer to such large fluctuations, with the variance growing as square of the mean, as Giant Number Fluctuations (GNF). Luria and Delbruck showed that spontaneous mutation processes in microbial populations exhibit GNF. We explore whether GNF can arise in other microbial ecologies. We study certain simple ecological models evolving via stochastic processes: (i) bi-directional mutation, (ii) lysis-lysogeny of bacteria by bacteriophage, and (iii) horizontal gene transfer (HGT). For the case of bi-directional mutation process, we show analytically exactly that the GNF relationship holds at large times. For the ecological model of bacteria undergoing lysis or lysogeny under viral infection, we show that if the viral population can be experimentally manipulated to stay quasi-stationary, the process of lysogeny maps essentially to one-way mutation process and hence the GNF property of the lysogens follows. Finally, we show that even the process of HGT may map to the mutation process at large times, and thereby exhibits GNF.

Recommendations

• Proliferation model dependence in fluctuation analysis: The neutral case
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Cites work

• A population birth-and-mutation process, I: explicit distributions for the number of mutants in an old culture of bacteria
• Analysis of the Luria–Delbrück distribution using discrete convolution powers
• scientific article; zbMATH DE number 3569467 (Why is no real title available?)
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• Progress of a half century in the study of the Luria-Delbrück distribution

Cited in

(1)

• Effects of bursty synthesis in organelle biogenesis

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