Proliferation model dependence in fluctuation analysis: The neutral case

DOI10.1007/S00285-009-0294-3MaRDI QIDQ604507zbMATH OpenOpenAlexWikidataFDO

Authors Wolfgang P. Angerer

Publication date 11 November 2010

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0604555

zbMATH Keywords

Bellman-Harris processBranching processesRenewal theory

Mathematics Subject Classification ID

Applications of branching processes (60J85) Applications of renewal theory (reliability, demand theory, etc.) (60K10) Problems related to evolution (92D15)

Abstract: We discuss the evaluation of Luria-Delbrueck fluctuation experiments under Bellman-Harris models of cell proliferation. It is shown that under certain very natural assumptions concerning the life-time distributions and the offspring distributions of mutant and non-mutant bacteria, the suitably normed and centered number of mutants contained in a large culture of bacteria converges to a stable random variable with index 1. The result obtains under the assumption that the mutation under consideration is neutral in the sense that on average, mutant cells produce the same number of offspring as non-mutant cells.

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Cites work

• A generalized Luria-Delbrück model
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• scientific article; zbMATH DE number 3049368 (Why is no real title available?)
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Cited in

(5)

• Accumulation of neutral mutations in growing cell colonies with competition
• Statistics for the Luria-Delbrück distribution
• Cellular replication limits in the Luria-Delbrück mutation model
• Giant number fluctuations in microbial ecologies
• A comparison of mtDNA deletion mutant proliferation mechanisms

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