Cellular replication limits in the Luria-Delbrück mutation model
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Publication:2357653
Abstract: Originally developed to elucidate the mechanisms of natural selection in bacteria, the Luria-Delbr"uck model assumed that cells are intrinsically capable of dividing an unlimited number of times. This assumption however, is not true for human somatic cells which undergo replicative senescence. Replicative senescence is thought to act as a mechanism to protect against cancer and the escape from it is a rate-limiting step in cancer progression. Here we introduce a Luria-Delbr"uck model that explicitly takes into account cellular replication limits in the wild type cell population and models the emergence of mutants that escape replicative senescence. We present results on the mean, variance, distribution, and asymptotic behavior of the mutant population in terms of three classical formulations of the problem. More broadly the paper introduces the concept of incorporating replicative limits as part of the Luria-Delbr"uck mutational framework. Guidelines to extend the theory to include other types of mutations and possible applications to the modeling of telomere crisis and fluctuation analysis are also discussed.
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Cites work
- A generalized Luria-Delbrück model
- An explicit representation of the Luria-Delbrück distribution
- Analysis of the Luria–Delbrück distribution using discrete convolution powers
- scientific article; zbMATH DE number 3569467 (Why is no real title available?)
- scientific article; zbMATH DE number 1321103 (Why is no real title available?)
- Improved inference of mutation rates. I: An integral representation for the Luria-Delbrück distribution
- Large population solution of the stochastic Luria-Delbrück evolution model
- Mathematical models for estimating mutation rates in cell populations
- On an unbiased and consistent estimator for mutation rates
- On the probability of random genetic mutations for various types of tumor growth
- Progress of a half century in the study of the Luria-Delbrück distribution
- Proliferation model dependence in fluctuation analysis: The neutral case
- Statistical and algorithmic methods for fluctuation analysis with SALVADOR as an implementation
- The fixed-size Luria-Delbrück model with a nonzero death rate
Cited in
(6)- Fluctuation analysis on mutation models with birth-date dependence
- The role of telomere shortening in carcinogenesis: a hybrid stochastic-deterministic approach
- Bursts of sectors in expanding bacterial colonies as a possible model for tumor growth and metastases
- Non-neutral role of replicative senescence in tissue homeostasis and tumorigenesis
- Toward a unique definition of the mutation rate
- Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture
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