A generalized Luria-Delbrück model

DOI10.1016/j.mbs.2005.07.003zbMath1076.92025OpenAlexW1966001093WikidataQ51965138 ScholiaQ51965138MaRDI QIDQ2576365

E. Georg Luebeck, Anup Dewanji, Suresh H. Moolgavkar

Publication date: 27 December 2005

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2005.07.003

zbMATH Keywords

fluctuation analysiscarcinogenesisbirth-death processGompertz growthLuria-Delbrück distributionfiltered Poisson processmutant clones

Mathematics Subject Classification ID

Signal detection and filtering (aspects of stochastic processes) (60G35) Applications of branching processes (60J85) Medical applications (general) (92C50) Cell biology (92C37)

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Cites Work

• A stochastic Gompertz birth-death process
• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• Improved inference of mutation rates. I: An integral representation for the Luria-Delbrück distribution
• Improved inference of mutation rates. II: Generalization of the Luria-Delbrück distribution for realistic cell-cycle time distributions
• Statistical and algorithmic methods for fluctuation analysis with SALVADOR as an implementation
• Progress of a half century in the study of the Luria-Delbrück distribution
• Estimation of Spontaneous Mutation Rates
• Analysis of the Luria–Delbrück distribution using discrete convolution powers
• Mathematical models for estimating mutation rates in cell populations
• An explicit representation of the Luria-Delbrück distribution
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