The fixed-size Luria-Delbrück model with a nonzero death rate

DOI10.1016/J.MBS.2007.04.007MaRDI QIDQ2472891zbMATH OpenOpenAlexWikidataFDO

Authors Natalia L. Komarova, Lin Wu, Pierre Baldi

Publication date 25 February 2008

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2007.04.007

zbMATH Keywords

cancerdiffusion approximationmutationsboundary layerdrug resistancestochastic modeling

Mathematics Subject Classification ID

Medical applications (general) (92C50) Signal detection and filtering (aspects of stochastic processes) (60G35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

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• Mathematical models for estimating mutation rates in cell populations
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Cited in

(11)

• Accumulation of neutral mutations in growing cell colonies with competition
• Mutation frequencies in a birth-death branching process
• A generalized Luria-Delbrück model
• Mutant number distribution in an exponentially growing population
• Stochastic modeling of cellular colonies with quiescence: an application to drug resistance in cancer
• The worst drug rule revisited: mathematical modeling of cyclic cancer treatments
• Universal asymptotic clone size distribution for general population growth
• Exact site frequency spectra of neutrally evolving tumors: a transition between power laws reveals a signature of cell viability
• Time inhomogeneous mutation models with birth date dependence
• Fluctuation analysis on mutation models with birth-date dependence
• Cellular replication limits in the Luria-Delbrück mutation model

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