Stability of a stochastically perturbed model of intracellular single-stranded RNA virus replication

DOI10.1142/S0218339019500049MaRDI QIDQ5230433zbMATH OpenFDO

Authors Leonid Shaikhet, Santiago F. Elena, A. Korobeinikov

Publication date 22 August 2019

Published in Journal of Biological Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1810.01688

zbMATH Keywords

direct Lyapunov methodLyapunov functionmathematical modelssRNA virusstabilitystochastic modelviral evolutionviral mutationsviral replicationvirus dynamics

Mathematics Subject Classification ID

Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10) Genetics and epigenetics (92D10) Problems related to evolution (92D15) Stochastic stability in control theory (93E15)

Abstract: Replication of single-stranded RNA virus can be complicated, compared to that of double-stranded virus, as it require production of intermediate antigenomic strands that then serve as template for the genomic-sense strands. Moreover, for ssRNA viruses, there is a variability of the molecular mechanism by which genomic strands can be replicated. A combination of such mechanisms can also occur: a fraction of the produced progeny may result from a stamping-machine type of replication that uses the parental genome as template, whereas others may result from the replication of progeny genomes. F. Mart'{i}nez et al. and J. Sardany'{e}s at al. suggested a deterministic ssRNA virus intracellular replication model that allows for the variability in the replication mechanisms. To explore how stochasticity can affect this model principal properties, in this paper we consider the stability of a stochastically perturbed model of ssRNA virus replication within a cell. Using the direct Lyapunov method, we found sufficient conditions for the stability in probability of equilibrium states for this model. This result confirms that this heterogeneous model of single-stranded RNA virus replication is stable with respect to stochastic perturbations of the environment.

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Cites work

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Cited in

(3)

• Modelling the stability of Stx lysogens
• ON EXPLORING EFFECTS OF MOLECULAR NOISE IN A SIMPLE VIRAL INFECTION MODEL
• About one method of stability investigation for nonlinear stochastic delay differential equations

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