Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours

DOI10.1016/J.JTBI.2013.07.019zbMATH Open1411.92088OpenAlexW2058779076WikidataQ43851035 ScholiaQ43851035MaRDI QIDQ2632151FDOQ2632151

Authors Nicolas Bonello, James Sampson, John Burn, Ian J. Wilson, Gail McGrown, Geoff P. Margison, Mary Thorncroft, Philip Crossbie, Andrew C. Povey, Mauro Santibanez-Koref, Kevin Walters

Publication date 14 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2013.07.019

zbMATH Keywords

model selectionBayesian analysisDNA methylationlung cancerMGMT

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08)

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Cites work

• Modeling DNA methylation in a population of cancer cells
• Parameter estimation for an immortal model of colonic stem cell division using approximate Bayesian computation
• Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals

Cited in

(8)

• Modeling dependence in methylation patterns with application to ovarian carcinomas
• Parameter estimation for an immortal model of colonic stem cell division using approximate Bayesian computation
• Modeling DNA methylation in a population of cancer cells
• Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals
• A stochastic model for the formation of spatial methylation patterns
• Data-driven selection and parameter estimation for DNA methylation mathematical models
• Application of Multidimensional Selective Item Response Regression Model for Studying Multiple Gene Methylation in SV40 Oncogenic Pathways
• A stochastic automata network description for spatial DNA-methylation models

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