The role of cell-cell adhesion in wound healing

DOI10.1007/S10955-006-9194-8MaRDI QIDQ2641398zbMATH OpenOpenAlexFDO

Authors Evgeniy Khain, Leonard M. Sander, Casey M. Schneider-Mizell

Publication date 20 August 2007

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0610015

zbMATH Keywords

cell-cell adhesionstochastic modelingwound healing

Mathematics Subject Classification ID

Lattice systems (Ising, dimer, Potts, etc.) and systems on graphs arising in equilibrium statistical mechanics (82B20) Statistical mechanics of magnetic materials (82D40) Cell movement (chemotaxis, etc.) (92C17)

Abstract: We present a stochastic model which describes fronts of cells invading a wound. In the model cells can move, proliferate, and experience cell-cell adhesion. We find several qualitatively different regimes of front motion and analyze the transitions between them. Above a critical value of adhesion and for small proliferation large isolated clusters are formed ahead of the front. This is mapped onto the well-known ferromagnetic phase transition in the Ising model. For large adhesion, and larger proliferation the clusters become connected (at some fixed time). For adhesion below the critical value the results are similar to our previous work which neglected adhesion. The results are compared with experiments, and possible directions of future work are proposed.

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Cites work

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Cited in

(18)

• Lattice-free models of directed cell motility
• The effect of domain growth on spatial correlations
• Proliferation of cells with aggregation and communication
• A semi-stochastic cell-based model for in vitro infected `wound' healing through motility reduction: a simulation study
• Dynamics of an expanding cell monolayer
• Travelling wave solutions in a negative nonlinear diffusion-reaction model
• Modeling cell size dynamics in a confined nonuniform dense cell culture
• Spatial point processes and moment dynamics in the life sciences: a parsimonious derivation and some extensions
• A stochastic model for wound healing
• Bifurcation analysis of critical values for wound closure outcomes in wound healing experiments
• A modified Pólya urn process and an index for spatial distributions with volume exclusion
• Adhesion of a blood platelet to injured tissue
• A stochastic model for wound healing
• The importance of volume exclusion in modelling cellular migration
• Inference of cell-cell interactions from population density characteristics and cell trajectories on static and growing domains
• Calibration of agent based models for monophasic and biphasic tumour growth using approximate Bayesian computation
• Cellular adhesion impact on epidermal wound healing
• Modeling keratinocyte wound healing dynamics: cell-cell adhesion promotes sustained collective migration

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