Fluctuations, responses and energetics of molecular motors

DOI10.1016/J.MBS.2006.11.003MaRDI QIDQ2643372zbMATH OpenOpenAlexWikidataFDO

Authors Takahiro Harada, Shin-ichi Sasa

Publication date 23 August 2007

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/cond-mat/0610757

zbMATH Keywords

Brownian motor modelenergeticsfluctuationsmechano-chemical enzymesmolecular motorpath-integral representationresponse

Mathematics Subject Classification ID

Diffusion processes (60J60) Brownian motion (60J65) Biophysics (92C05) Medical applications (general) (92C50)

Abstract: A novel equality relating the rate of energy dissipation to a degree of violation of the fluctuation-response relation (FRR) in nonequilibrium Langevin systems is described. The FRR is a relation between the correlation function of the fluctuations and the response function of macroscopic variables. Although it has been established that the FRR holds in equilibrium, physical significance of violation of the FRR in nonequilibrium systems has been under debate. Recently, the authors have found that an extent of the FRR violation is related in a simple equality to the rate of energy dissipation into the environment in nonequilibrium Langevin systems. In this paper, we fully explain the FRR, the FRR violation, and the new equality with regard to a Langevin model termed a Brownian motor model, which is considered as a simple model of a biological molecular motor. Furthermore, applications of our result to experimental studies of molecular motors are discussed, and, as an illustration, we predict the value of a new time constant regarding the motion of a KIF1A, which is a kind of single-headed kinesin.

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Cites work

• Brownian motors: noisy transport far from equilibrium
• Exact transformation of a Langevin equation to a fluctuating response equation
• Handbook of stochastic methods for physics, chemistry and natural sciences.
• The Fokker-Planck equation. Methods of solutions and applications.

Cited in

(8)

• Reverse-engineering of biochemical reaction networks from spatio-temporal correlations of fluorescence fluctuations
• Violation of the second fluctuation-dissipation relation and entropy production in nonequilibrium medium
• Switching statistics of a flagellar motor: first-passage time and dynamic binding
• Force generation and step-size fluctuations in a dynein motor
• The entropy and efficiency of a molecular motor model
• The Role of Protein Flexibility in Molecular Motor Function: Coupled Diffusion in a Tilted Periodic Potential
• Effective temperatures for single particle system under dichotomous noise
• Energy conversion by molecular motors coupled to nucleotide hydrolysis

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