A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

DOI10.1016/J.JTBI.2022.111239MaRDI QIDQ2676076zbMATH OpenOpenAlexWikidataFDO

Authors Claudiu V. Giuraniuc, Shabana Zain, Shahmama Ghafoor, Stefan Hoppler

Publication date 27 September 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://arxiv.org/abs/2203.00779

zbMATH Keywords

\(\beta\)-cateninWNT signallingxenopus

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Developmental biology, pattern formation (92C15) Systems biology, networks (92C42)

Abstract: There are two phases of Wnt signalling in early vertebrate embryogenesis: very early, maternal Wnt signalling promotes dorsal development, and slightly later, zygotic Wnt signalling promotes ventral and lateral mesoderm induction. However, recent molecular biology analysis has revealed more complexity among the direct Wnt target genes, with at least five classes. Here in order to test the logic and the dynamics of a new Gene Regulatory Network model suggested by these discoveries we use mathematical modelling based on ordinary differential equations (ODEs). Our mathematical modelling of this Gene Regulatory Network reveals that a simplified model, with one "super-gene" for each class is sufficient to a large extent to describe the regulatory behaviour previously observed experimentally.

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(6)

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