An analytical approach of one-compartmental pharmacokinetic models with sigmoidal Hill elimination

DOI10.1007/S11538-022-01078-4zbMath1506.92045OpenAlexW4295530028WikidataQ114222248 ScholiaQ114222248MaRDI QIDQ2676650

Xiaotian Wu, Hao Zhang, Jun Li

Publication date: 28 September 2022

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-022-01078-4

zbMATH Keywords

closed-form solutionpharmacokinetic modelsLambert \(W\) functionMichaelis-Menten modelHill coefficientbolus drug administrationpharmacokinetic surrogatessigmoidal Hill eliminationtranscendent function

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50) Explicit solutions, first integrals of ordinary differential equations (34A05)

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Cites Work

• Variability and singularity arising from poor compliance in a pharmacokinetic model. II: The multi-oral case
• Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model
• On the Lambert \(w\) function
• Analytical solution and exposure analysis of a pharmacokinetic model with simultaneous elimination pathways and endogenous production: the case of multiple dosing administration

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