Bifurcation analysis of a free boundary model of vascular tumor growth with a necrotic core and chemotaxis

DOI10.1007/S00285-022-01862-9MaRDI QIDQ2679515zbMATH OpenOpenAlexWikidataFDO

Authors Min-Jhe Lu, Wenrui Hao, Bei Hu, Shuwang Li

Publication date 23 January 2023

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2212.06389

zbMATH Keywords

bifurcationchemotaxisfree boundary problemnecrotic corevascular tumor

Mathematics Subject Classification ID

Bifurcations in context of PDEs (35B32) Stability in context of PDEs (35B35) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35)

Abstract: A considerable number of research works has been devoted to the study of tumor models. Several biophysical factors, such as cell proliferation, apoptosis, chemotaxis, angiogenesis and necrosis, have been discovered to have an impact on the complicated biological system of tumors. An indicator of the aggressiveness of tumor development is the instability of the shape of the tumor boundary. Complex patterns of tumor morphology have been explored by Lu, Min-Jhe et al. [Nonlinear simulation of vascular tumor growth with chemotaxis and the control of necrosis, Journal of Computational Physics 459 (2022): 111153]. In this paper, we continue to carry out a bifurcation analysis on such a vascular tumor model with a controlled necrotic core and chemotaxis. This bifurcation analysis, to the parameter of cell proliferation, is built on the explicit formulas of radially symmetric steady-state solutions. By perturbing the tumor free boundary and establishing rigorous estimates of the free boundary system, %applying the Hanzawa transformation, we prove the existence of the bifurcation branches with Crandall-Rabinowitz theorem. The parameter of chemotaxis is found to influence the monotonicity of the bifurcation point as the mode $l$ increases both theoretically and numerically.

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Cited in

(13)

• Stationary solutions of a free boundary problem modeling the growth of vascular tumors with a necrotic core
• Nonlinear simulation of vascular tumor growth with chemotaxis and the control of necrosis
• Complex far-field geometries determine the stability of solid tumor growth with chemotaxis
• Bifurcation for a free boundary problem modeling the growth of necrotic multilayered tumors
• Bifurcation analysis and nonlinear decay of a tumor in the presence of an immune response
• Analysis of a free boundary problem for vascularized tumor growth with a necrotic core and time delays
• Symmetry-breaking bifurcation analysis of a free boundary problem modeling 3-dimensional tumor cord growth
• Analysis of a nonlinear free boundary problem modeling the radial growth of two-layer tumors
• Nonsymmetric traveling wave solution to a Hele-Shaw type tumor growth model
• On determination of the bifurcation type for a free boundary problem modeling tumor growth
• Symmetry-breaking bifurcation for necrotic tumor model with two free boundaries
• Optimal control of treatment in a free boundary problem modeling multilayered tumor growth
• A Geometric Local Parameterization Method for Generalized Hele-Shaw Free Boundary Problems with Source Terms

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