Assessing the therapeutic response of tumors to hypoxia-targeted prodrugs with an \textit{in silico} approach

DOI10.3934/MBE.2022511MaRDI QIDQ2693585zbMATH OpenOpenAlexFDO

Authors Defne Yilmaz, Mert Tuzer, Mehmet Burcin Unlu

Publication date 24 March 2023

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3934/mbe.2022511

zbMATH Keywords

cancerchemotherapyhypoxiahypoxia-activated prodrugsmathematical modelingmultiscale modeltreatment response

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37) Medical applications (general) (92C50)

Cites work

• Modeling the spatial distribution of chronic tumor hypoxia: implications for experimental and clinical studies
• Role of hypoxia-activated prodrugs in combination with radiation therapy: an in silico approach
• The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems

Cited in

(1)

• Introducing Drug Transport Early in the Design of Hypoxia Selective Anticancer Agents Using a Mathematical Modelling Approach

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