An exposure-weighted score test for genetic associations integrating environmental risk factors

DOI10.1111/BIOM.12328MaRDI QIDQ2803474zbMATH OpenOpenAlexWikidataFDO

Authors Summer S. Han, Philip S. Rosenberg, Arpita Ghosh, Maria Landi, Neil Caporaso, Nilanjan Chatterjee

Publication date 4 May 2016

Published in Biometrics (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc4575251

zbMATH Keywords

score testGWASgene-environment interactionSNPsenvironmental exposures

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Recommendations

• Testing for genetic association in the presence of linkage and gene-covariate interactions
• Using shared genetic controls in studies of gene-environment interactions
• Testing for gene-environment interaction under exposure misspecification
• Determining Gene­Environment Interaction Using Projected Score Method
• Testing and Estimating Gene-Environment Interactions in Family-Based Association Studies

Cites work

• Hypothesis Testing When a Nuisance Parameter is Present Only Under the Alternative
• Semiparametric maximum likelihood estimation exploiting gene-environment independence in case-control studies
• Testing for gene-environment and gene-gene interactions under monotonicity constraints

Cited in

(3)

• Competing risk modeling and testing for X-chromosome genetic association
• A semiparametric efficient estimator in case-control studies for gene-environment independent models
• Identifying genetic variants for addiction via propensity score adjusted generalized Kendall's tau

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