Dose response signal detection under model uncertainty

DOI10.1111/BIOM.12357MaRDI QIDQ2809526zbMATH OpenOpenAlexWikidataFDO

Authors Stefanie Titoff, Stanislav Volgushev, Frank Bretz, Holger Dette

Publication date 30 May 2016

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/biom.12357

zbMATH Keywords

nonlinear regressionlikelihood ratio testmodel identificationcontrast testsdose response studies

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic distribution theory in statistics (62E20)

Recommendations

• Likelihood ratio tests for a dose-response effect using multiple nonlinear regression models
• A Dose-Response Model Incorporating Nonlinear Kinetics
• Testing effect of a drug using multiple nested models for the dose-response
• Maximally Selected Rank Statistics for Dose-Response Problems
• BMA‐Mod: A Bayesian model averaging strategy for determining dose‐response relationships in the presence of model uncertainty

Cites work

• scientific article; zbMATH DE number 1741808 (Why is no real title available?)
• A Note on Nonparametric Estimation of the Effective Dose in Quantal Bioassay
• Adaptive dose-finding: Proof of concept with type I error control
• Admissibility of the likelihood ratio test when a nuisance parameter is present only under the alternative
• Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests
• Asymptotics for likelihood ratio tests under loss of identifiability
• Bayesian Nonparametric Estimation of Continuous Monotone Functions with Applications to Dose–Response Analysis
• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• Hypothesis Testing When a Nuisance Parameter is Present Only Under the Alternative
• Multiple Test Procedures for Dose Finding
• Multiple Test Procedures for Identifying the Maximum Safe Dose
• On asymptotically optimal tests under loss of identifiability in semiparametric models
• On the Distribution of the Likelihood Ratio
• Optimal Tests when a Nuisance Parameter is Present Only Under the Alternative
• Optimal designs for the emax, log-linear and exponential models
• Response-adaptive dose-finding under model uncertainty
• Testing the Statistical Certainty of a Response to Increasing Doses of a Drug
• The Large-Sample Distribution of the Likelihood Ratio for Testing Composite Hypotheses

Cited in

(7)

• Comparison of different approaches for dose response analysis
• Generalized multiple contrast tests in dose-response studies
• The Tukey trend test: Multiplicity adjustment using multiple marginal models
• Dose-response relationship from longitudinal data with response-dependent dose modification using likelihood methods
• cLRT-Mod: an efficient methodology for pharmacometric model-based analysis of longitudinal phase II dose finding studies under model uncertainty
• Identifying Alert Concentrations Using a Model-Based Bootstrap Approach
• Likelihood ratio tests for a dose-response effect using multiple nonlinear regression models

Describes a project that uses

Uses Software

• bnpmr

This page was built for publication: Dose response signal detection under model uncertainty

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2809526)