Dose response signal detection under model uncertainty

DOI10.1111/BIOM.12357zbMATH Open1419.62338OpenAlexW2152290665WikidataQ40675281 ScholiaQ40675281MaRDI QIDQ2809526FDOQ2809526

Authors: Stefanie Titoff, Stanislav Volgushev, Frank Bretz, Holger Dette 

Publication date: 30 May 2016

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.12357

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zbMATH Keywords

nonlinear regressionlikelihood ratio testmodel identificationcontrast testsdose response studies

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic distribution theory in statistics (62E20)

Cites Work

• Hypothesis Testing When a Nuisance Parameter is Present Only Under the Alternative
• Optimal Tests when a Nuisance Parameter is Present Only Under the Alternative
• The Large-Sample Distribution of the Likelihood Ratio for Testing Composite Hypotheses
• On the Distribution of the Likelihood Ratio
• Bayesian Nonparametric Estimation of Continuous Monotone Functions with Applications to Dose–Response Analysis
• Optimal designs for the emax, log-linear and exponential models
• Asymptotics for likelihood ratio tests under loss of identifiability
• Admissibility of the likelihood ratio test when a nuisance parameter is present only under the alternative
• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• A Note on Nonparametric Estimation of the Effective Dose in Quantal Bioassay
• Title not available (Why is that?)
• Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests
• Multiple Test Procedures for Dose Finding
• Testing the Statistical Certainty of a Response to Increasing Doses of a Drug
• Response-adaptive dose-finding under model uncertainty
• On asymptotically optimal tests under loss of identifiability in semiparametric models
• Multiple Test Procedures for Identifying the Maximum Safe Dose
• Adaptive dose-finding: Proof of concept with type I error control

Cited In (7)

• Comparison of different approaches for dose response analysis
• Generalized multiple contrast tests in dose-response studies
• The Tukey trend test: Multiplicity adjustment using multiple marginal models
• cLRT-Mod: an efficient methodology for pharmacometric model-based analysis of longitudinal phase II dose finding studies under model uncertainty
• Dose-response relationship from longitudinal data with response-dependent dose modification using likelihood methods
• Identifying Alert Concentrations Using a Model-Based Bootstrap Approach
• Likelihood ratio tests for a dose-response effect using multiple nonlinear regression models

Uses Software

• bnpmr

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