Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests

DOI10.1002/bimj.4710390408zbMath0890.62080OpenAlexW1978970392MaRDI QIDQ4360101

Markus Neuhäuser, Hans Koch, Ludwig A. Hothorn

Publication date: 20 October 1997

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.4710390408

zbMATH Keywords

multiple contrast teststrend testsminimum effective dosedose finding

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric inference under constraints (62F30)

Related Items

Numerical computation of multivariatet-probabilities with application to power calculation of multiple contrasts ⋮ Unnamed Item ⋮ Basic concepts of multiple tests -- a survey ⋮ Comparison of different approaches for dose response analysis ⋮ An extension of the Williams trend test to general unbalanced linear models ⋮ Dose response signal detection under model uncertainty ⋮ A hybrid method to estimate the minimum effective dose for monotone and non‐monotone dose–response relationships ⋮ An exact Cochran--Armitage test for trend when dose--response shapes are a priori unknown. ⋮ IDENTIFYING THE MAXIMUM SAFE DOSE: A MULTIPLE TESTING APPROACH

Uses Software

• SAS
• SAS/STAT

Cites Work

• An Analogue of Jonckheere's Trend Test for Parametric and Dichotomous Data
• A DISTRIBUTION-FREE k-SAMPLE TEST AGAINST ORDERED ALTERNATIVES