Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests

DOI10.1002/BIMJ.4710390408zbMATH Open0890.62080OpenAlexW1978970392MaRDI QIDQ4360101FDOQ4360101

Authors: Ludwig A. Hothorn, Markus Neuhäuser, Hans Koch 

Publication date: 20 October 1997

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.4710390408

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zbMATH Keywords

multiple contrast teststrend testsminimum effective dosedose finding

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric inference under constraints (62F30)

Cites Work

• A DISTRIBUTION-FREE k-SAMPLE TEST AGAINST ORDERED ALTERNATIVES
• An Analogue of Jonckheere's Trend Test for Parametric and Dichotomous Data

Cited In (12)

• Adjusted Regression Trend Test for a Multicenter Clinical Trial
• Comparison of different approaches for dose response analysis
• A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships
• Multiple testing for identifying effective and safe treatments
• An extension of the Williams trend test to general unbalanced linear models
• Numerical computation of multivariatet-probabilities with application to power calculation of multiple contrasts
• An exact Cochran--Armitage test for trend when dose--response shapes are a priori unknown.
• Basic concepts of multiple tests -- a survey
• Dose response signal detection under model uncertainty
• Adaptive dose-finding: Proof of concept with type I error control
• Efficiency of bridging between related dose finding studies
• IDENTIFYING THE MAXIMUM SAFE DOSE: A MULTIPLE TESTING APPROACH

Uses Software

• SAS
• SAS/STAT

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