Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests

DOI10.1002/BIMJ.4710390408MaRDI QIDQ4360101zbMATH OpenOpenAlexFDO

Authors Ludwig A. Hothorn, Markus Neuhäuser, Hans Koch

Publication date 20 October 1997

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.4710390408

zbMATH Keywords

multiple contrast teststrend testsminimum effective dosedose finding

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric inference under constraints (62F30)

Recommendations

• Multiple Test Procedures for Dose Finding
• Some new multiple-test procedures for dose finding
• On sequential closed testing dose groups with a control
• Multiple testing for dose finding

Cites work

• A DISTRIBUTION-FREE k-SAMPLE TEST AGAINST ORDERED ALTERNATIVES
• An Analogue of Jonckheere's Trend Test for Parametric and Dichotomous Data

Cited in

(12)

• Adjusted Regression Trend Test for a Multicenter Clinical Trial
• Comparison of different approaches for dose response analysis
• An extension of the Williams trend test to general unbalanced linear models
• Multiple testing for identifying effective and safe treatments
• A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships
• Numerical computation of multivariatet-probabilities with application to power calculation of multiple contrasts
• An exact Cochran--Armitage test for trend when dose--response shapes are a priori unknown.
• Basic concepts of multiple tests -- a survey
• Dose response signal detection under model uncertainty
• Adaptive dose-finding: Proof of concept with type I error control
• Efficiency of bridging between related dose finding studies
• IDENTIFYING THE MAXIMUM SAFE DOSE: A MULTIPLE TESTING APPROACH

Describes a project that uses

Uses Software

• SAS/STAT
• SAS

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