IDENTIFYING THE MAXIMUM SAFE DOSE: A MULTIPLE TESTING APPROACH

DOI10.1081/BIP-100101010MaRDI QIDQ4512647zbMATH OpenWikidataFDO

Authors Ludwig A. Hothorn, Dieter Hauschke

Publication date 5 November 2000

Published in Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

zbMATH Keywords

multiple testingstepwise testing procedureintersection-union textmaximum safe doseno-observed-adverse-effect doseNOAED

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

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• Some new multiple-test procedures for dose finding

Cites work

• scientific article; zbMATH DE number 1332899 (Why is no real title available?)
• A Note on Multiple Testing Procedures in Dose Finding
• A Simple Approach to Testing Homogeneity of Order-Constrained Means
• APPROXIMATE SAMPLE SIZES FOR TESTING HYPOTHESES ABOUT THE RATIO AND DIFFERENCE OF TWO MEANS
• Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests
• Bioequivalence trials, intersection-union tests and equivalence confidence sets. With comments and a rejoinder by the authors
• Distribution-free tests for comparing several treatments with a control
• Modified Sequentially Rejective Multiple Test Procedures
• Multiple Test Procedures for Dose Finding
• On the use of the ratio or the odds ratio of cure rates in therapeutic equivalence clinical trials with binary endpoints
• Ordered tests in the analysis of variance
• Some new multiple-test procedures for dose finding
• Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

Cited in

(6)

• Assessing the non-inferiority of a new treatment in a three-arm trial with unknown coefficient of variation
• Multiple testing for identifying effective and safe treatments
• Identification of minimum effective dose based on ratio of a normally distributed data under heteroscedasticity
• Power and sample size determination for a stepwise test procedure for finding the maximum safe dose
• Biostatistical assessment of mutagenicity studies: a stepwise confidence procedure
• Multiple Test Procedures for Identifying the Maximum Safe Dose

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