Qualitative analysis of tumor growth model under antiangiogenic therapy - choosing the effective operating point and design parameters for controller design

DOI10.1002/oca.2196zbMath1348.93131OpenAlexW1617532289MaRDI QIDQ2830286

Levente Kovács, István Á. Harmati, Johanna Sápi, Dániel András Drexler, Zoltán Sápi

Publication date: 28 October 2016

Published in: Optimal Control Applications and Methods (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/oca.2196

zbMATH Keywords

linear state feedbackstate observerpole placement methodLQ optimal control method

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Nonlinear systems in control theory (93C10) Medical applications (general) (92C50) Linearizations (93B18) Pole and zero placement problems (93B55) Linear-quadratic optimal control problems (49N10) Cell biology (92C37) Control/observation systems governed by ordinary differential equations (93C15)

Related Items (3)

Modeling of tumor growth incorporating the effects of necrosis and the effect of Bevacizumab ⋮ Tumour growth control: analysis of alternative approaches ⋮ Closed-loop control of tumor growth by means of anti-angiogenic administration

Cites Work

• Optimal scheduling of radiotherapy and angiogenic inhibitors
• Angiogenesis inhibition and tumor-immune interactions with chemotherapy by a control set-valued method
• A procedure for designing linear functional observers
• On optimal delivery of combination therapy for tumors
• Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)
• A bi-parametric model for the tumour angiogenesis and antiangiogenesis therapy
• AntiAngiogenic Therapy in Cancer Treatment as an Optimal Control Problem
• Realizable protocols for optimal administration of drugs in mathematical models for anti-angiogenic treatment

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