Qualitative analysis of tumor growth model under antiangiogenic therapy -- choosing the effective operating point and design parameters for controller design

DOI10.1002/OCA.2196MaRDI QIDQ2830286zbMATH OpenOpenAlexFDO

Authors Johanna Sápi, Dániel A. Drexler, István Harmati, Zoltán Sápi, Levente Kovács

Publication date 28 October 2016

Published in Optimal Control Applications \& Methods (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/oca.2196

zbMATH Keywords

state observerpole placement methodlinear state feedbackLQ optimal control method

Mathematics Subject Classification ID

Medical applications (general) (92C50) Linear-quadratic optimal control problems (49N10) Applications of optimal control and differential games (49N90) Cell biology (92C37) Linearizations (93B18) Pole and zero placement problems (93B55) Nonlinear systems in control theory (93C10) Control/observation systems governed by ordinary differential equations (93C15)

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Cites work

• A bi-parametric model for the tumour angiogenesis and antiangiogenesis therapy
• A procedure for designing linear functional observers
• Angiogenesis inhibition and tumor-immune interactions with chemotherapy by a control set-valued method
• AntiAngiogenic Therapy in Cancer Treatment as an Optimal Control Problem
• On optimal delivery of combination therapy for tumors
• Optimal scheduling of radiotherapy and angiogenic inhibitors
• Realizable protocols for optimal administration of drugs in mathematical models for anti-angiogenic treatment
• Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)

Cited in

(3)

• Tumour growth control: analysis of alternative approaches
• Modeling of tumor growth incorporating the effects of necrosis and the effect of Bevacizumab
• Closed-loop control of tumor growth by means of anti-angiogenic administration

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