Qualitative analysis of tumor growth model under antiangiogenic therapy -- choosing the effective operating point and design parameters for controller design

DOI10.1002/OCA.2196zbMATH Open1348.93131OpenAlexW1617532289MaRDI QIDQ2830286FDOQ2830286

Authors: Johanna Sápi, Dániel A. Drexler, István Harmati, Zoltán Sápi, Levente Kovács 

Publication date: 28 October 2016

Published in: Optimal Control Applications \& Methods (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/oca.2196

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zbMATH Keywords

state observerpole placement methodlinear state feedbackLQ optimal control method

Mathematics Subject Classification ID

Medical applications (general) (92C50) Linear-quadratic optimal control problems (49N10) Applications of optimal control and differential games (49N90) Cell biology (92C37) Linearizations (93B18) Pole and zero placement problems (93B55) Nonlinear systems in control theory (93C10) Control/observation systems governed by ordinary differential equations (93C15)

Cites Work

• Optimal scheduling of radiotherapy and angiogenic inhibitors
• On optimal delivery of combination therapy for tumors
• Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)
• AntiAngiogenic Therapy in Cancer Treatment as an Optimal Control Problem
• Angiogenesis inhibition and tumor-immune interactions with chemotherapy by a control set-valued method
• A procedure for designing linear functional observers
• Realizable protocols for optimal administration of drugs in mathematical models for anti-angiogenic treatment
• A bi-parametric model for the tumour angiogenesis and antiangiogenesis therapy

Cited In (3)

• Tumour growth control: analysis of alternative approaches
• Modeling of tumor growth incorporating the effects of necrosis and the effect of Bevacizumab
• Closed-loop control of tumor growth by means of anti-angiogenic administration

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