Calculating asymptotic significance levels of the constrained likelihood ratio test with application to multivariate genetic linkage analysis

DOI10.2202/1544-6115.1456MaRDI QIDQ2864099zbMATH OpenOpenAlexWikidataFDO

Authors Nathan J. Morris, Robert Elston, Catherine M. Stein

Publication date 5 December 2013

Published in Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc2861321

zbMATH Keywords

one-sided testingvariance component testingnonstandard conditionsconstrained hypothesis testingmultivariate linkage analysis

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Hypothesis testing in multivariate analysis (62H15) Genetics and epigenetics (92D10)

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Cited in

(5)

• Reconsidering the asymptotic null distribution of likelihood ratio tests for genetic linkage in multivariate variance components models under complete pleiotropy
• Asymptotic properties of likelihood ratio test statistics in affected‐sib‐pair analysis
• Assessing statistical significance in variance components linkage analysis: a theoretical justification
• On the asymptotic distribution of likelihood ratio test when parameters lie on the boundary
• On the likelihood ratio tests in bivariate ACDE models

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